Cholangiocelulární karcinom (cholangiocarcinoma, CCC) a duktální adenokarcinom pankreatu (pancreatic cancer, PC) jsou hlavní příčinou maligní biliární obstrukce. U většiny pacientů je onemocnění diagnostikováno v pokročilém ...

Hypoxie hraje zásadní roli v biologii nádorových onemocnění - ovlivňuje jejich růst, šíření a citlivost na protinádorovu léčbu. Postihuje hlavně rychle rostoucí tumory. V důsledku hypoxie dochází k aktivaci mnoha procesů, ...

I přes rychlý rozvoj medikamentózní léčby a zlepšení dostupnosti inovativní terapie vede přirozený průběh Crohnovy choroby až u 50 % pacientů ke vzniku střevní stenózy, která vyžaduje chirurgické řešení. Farmakologická ...

Úvod: Chirurgická léčba vestibulárního schwannomu je spojena s kompletní nebo částečnou resekcí vestibulárního nervu a obvykle vede k rozvoji jednostranné akutní periferní nebo kombinované vestibulární léze, která se u ...

Proteolytické systémy hrají klíčovou roli u medicínsky významných členovců v procesech, jako jsou interakce parazita s hostitelem a rozvoj alergické hypersenzitivity. Tato disertační práce se zaměřuje na katepsinové proteázy ...

Souhrn Úvod a cíl: Neuropeptidy se vyznačují rozsáhlými centrálními a periferními účinky, které mají regulační a modulační roli, která by mohla být v blízké budoucnosti využívána i terapeuticky. Jedním z těchto neuropeptidů ...

(CZ) Proteiny ORM a ORMDL patří do skupiny vysoce homologních, evolučně konzervovaných transmembránových proteinů lokalizovaných v endoplazmatickém retikulu (ER). Savci mají tři proteiny ORMDL, ORMDL1, ORMDL2 a ORMDL3, ...

This dissertation investigates the long-term cognitive consequences of acute methanol poisoning in surviving patients. The primary aim is to characterize the scope and temporal stability of cognitive deficits over the years ...

Drug abuse is a major public health problem with a growing trend worldwide. A way of circumventing the control of illicit drugs by regulatory authorities is the synthesis of new psychoactive substances, which have supplied ...

Introduction: Current diabetes treatment guidelines emphasize the importance of early, intensive, and structured education immediately after diagnosis, as well as the prompt initiation of continuous (CGM) or flash glucose ...

Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by chronic muscle inflammation, leading to the destruction of the autologous cells and ultimately to damage entire organs. From a ...

Parkinson's disease (PD) is characterized by typical motor and non-motor symptoms. Non- motor symptoms in PD also include cognitive deficits. Cognitive deficits can be present in the early stages of the disease and can ...

Hernia surgeries belong among the most common surgical procedures performed in elective and emergency settings. The use of surgical mesh is now the standard in nearly all types of hernia surgeries, as reflected in international ...

The bone marrow microenvironment critically regulates leukemic cell fate through a dynamic interplay of stromal contact, soluble signals and oxygen tension. This study systematically dissected how different co-cultivation ...

(IN ENGLISH) INTRODUCTION: Over the last fifteen years, there has been a decline in smoking, alcohol consumption and illicit drug use among Czech adolescents, which has been attributed to changes in relation to digital ...

Advancements in the field of transplant medicine have led to significant improvements in the survival rates of patients receiving solid organ transplants in recent decades. Nevertheless, this immense achievement has given ...

Ribosomal DNA (rDNA) encodes the RNA components of ribosomes, and its transcription is tightly regulated to meet cellular demands. While rDNA has long been studied, its intergenic spacer (IGS) was historically considered ...

Electroconvulsive therapy (ECT) is one of the most effective methods of treatment of severe mental disorders. However, it is often perceived negatively by both general public and professionals. Theoretical part of this ...

Musculoskeletal disorders, such as osteoporosis, osteoarthritis (OA), and axial spondyloarthritis (axSpA), represent a significant burden for patients in terms of morbidity, functional impairment, and economic impact. ...

Women's Religious Institutions and Nursing Care in the 19th and 20th Centuries Antonín Šťastný Institute for History of Medicine and Foreign Languages, First Faculty of Medicine, Charles University The topic of women's ...

(EN) Cardiovascular disease (CVD), especially atherosclerotic CVD (ASCVD), remains the leading cause of morbidity and mortality not only in the Czech Republic but also globally. ASCVD are defined by a number of non-/modifiable ...

in English language Cross-linked gelatin-based hydrogels (GBH) have emerged as a biocompatible, biodegradable, inexpensive, and versatile platform for in vitro/in vivo cell-growing and tissue regeneration. Recently, a new ...

The diploma thesis Diet and alternative treatment of idiopathic intestinal inflammation deals with the influence of given dietary regimens on these diseases and the effectiveness of alternative treatment using selected ...

(Czech version) Tumor nekrotizující faktor (TNF) je silný prozánětlivý cytokin, který je nezbytný k ochraně organismu před různými infekcemi. Dysregulace signální dráhy TNF je spojena s řadou autoimunitních onemocnění, ...

1. Lékařská fakulta University Karlovy PhDr. Petra Winnette PhD 2025 Differences in Socio-emotional Development as a Function of Early Experiences in Caregiving Relationships Rozdíly v sociálně-emocionálním vývoji pod ...

Objective and background: The reduced health-related quality of life (HRQoL) has been demonstrated in narcolepsy type 1 (NT1), whereas data on narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) remain limited. This ...

Metabolic syndrome (MetS) is a complex disorder characterized by insulin resistance. Its increasing prevalence worldwide highlights the need for effective strategies beyond pharmacotherapy to manage this condition. Among ...

This dissertation focuses on families in which parents suffer from mental disorders and raise minor children. These children represent a particularly vulnerable group at higher risk of developing and progressing their own ...

Recently developed synthetic polymer conjugates of N-(2-hydroxypropyl) methacrylamide (HPMA) in combination with low-molecular-weight ligands, called iBodies, alongside with small molecular probes, represent a promising ...

Background: A drug consumption room is a specialized harm reduction service that provides a hygienic and safe environment for drug use under the supervision of trained professionals. The first injecting room in the Czech ...

1 Abstract The pathophysiology of tremor is diverse and, in some cases, not fully elucidated. In this thesis, we focus mainly on head tremor, which is a common symptom of essential tremor (ET), and cervical dystonia (CD). ...

Cíle studie: Primárním cílem bylo posoudit, zda specializované ultrazvukové vyšetření není horší než počítačová tomografie s podáním kontrastní látky (CT, contrast-enhanced computed tomography) a než celotělová magnetická ...

In drug discovery, high-throughput screening is often employed to evaluate thousands to millions compounds against clinically relevant enzymes. In this dissertation, the DNA-linked Inhibitor Antibody Assay (DIANA) was ...

Cardiac allograft vasculopathy (CAV) is a serious complication of orthotopic heart transplantation (HTx) and is a leading cause of long-term graft failure and late mortality. This thesis is based on two observational studies ...

The presented dissertation primarily focuses on examining the use of SPECT/CT in the surgical treatment of degenerative spine disorders, including degeneration of intervertebral discs, adjacent vertebral endplates, vertebral ...

Spinal fractures account for 2-5 % of all skeletal injuries in children. While upper cervical spine injuries are rare in the pediatric population, thoracolumbar spine injuries are more common. The first aim of our study ...

Background: Addiction specialist is a non-medical healthcare profession specializing in the prevention, treatment and/or harm reduction of risks and disorders related to the use of alcohol, tobacco products and other ...

Background: In the course of the last years, the possibilities for education in the field of addictology have changed considerably. Education in clinical addictology was launched, the S4 course was relaunched, the possibility ...

Title: Smart Home and its Use in the Occupational Therapy; With a Focus on Seniors Abstract: The bachelor thesis focuses on smart home and its use in the occupational therapy. The aim of the theoretical part is to describe ...

BACHELOR THESIS ABSTRACT Name, Surname: Sofie Klonová Supervisor: Mgr. Marianna Kačeňáková Title: Possibilities for Collaboration Between Occupational Therapists and Parents of Children With Cancer Abstract: The bachelor's ...