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Farmakokinetika léčiv u alternativních cest podání
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 2. 2. 2026Alternative routes of drug administration offer a promising perspective for targeted therapy, where increased bioavailability at the site of action combined with acceptable systemic exposure leads to enhanced therapeutic ... -
Identification and detail characterisation of the compounds inhibiting endonuclease activity of influenza A polymerase and L protein of Rift Valley Fever virus
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 3. 2. 2026Influenza and bunyaviruses pose significant public health challenges due to their high mutation rates, zoonotic potential, and limited antiviral therapies. Due to these attributes, both viruses are selected by the World ... -
Vzájemný vztah exprese PD-L1, hustoty CD8+ tumor infiltrujících lymfocytů a primárních řasinek u adenokarcinomu plic a pankreatu
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 12. 2. 2026Association of the combined parameters including PD-L1 expression, CD8+ tumor infiltrating lymphocytes and the frequency of primary cilia with the outcome in lung adenocarcinoma Blanka Rosová Lung adenocarcinomas, as well ... -
Charakterizace sestřihových forem mRNA genů predisponujících ke vzniku dědičných nádorových onemocnění
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 5. 2. 2026This study aimed to increase the efficiency and accuracy of molecular genetic diagnostics of hereditary cancer predispositions by implementing targeted RNA next- generation sequencing (RNA NGS) into routine laboratory ... -
Význam vybraných markerů nutričního stavu dětí a dospívajících s mentální anorexií se speciálním zřetelem k lipidovému a proteinovému metabolismu
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 19. 2. 2026Introduction: Anorexia nervosa (AN) is a serious psychiatric disorder that can be considered a model of simple starvation. The highest risk of AN onset occurs during adolescence, and the prevalence of AN among Czech ...
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