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Ženské řeholní instituce a ošetřovatelská péče v 19. a 20. století
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 4. 6. 2025Women's Religious Institutions and Nursing Care in the 19th and 20th Centuries Antonín Šťastný Institute for History of Medicine and Foreign Languages, First Faculty of Medicine, Charles University The topic of women's ... -
Trendy v užívání návykových látek a faktory související s rizikovým užíváním návykových látek mezi českými adolescenty: analýza dat mezinárodní opakované průřezové dotazníkové studie ESPAD
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 15. 4. 2025(IN ENGLISH) INTRODUCTION: Over the last fifteen years, there has been a decline in smoking, alcohol consumption and illicit drug use among Czech adolescents, which has been attributed to changes in relation to digital ... -
Preclinical biomarkers of neurodegeneration in alpha-synucleinopathies
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 16. 3. 2026Isolated Rapid Eye Movement (REM) Sleep Behavior Disorder (iRBD) is a strong prodromal marker for alpha-synucleinopathies like Parkinson's disease (PD). The iden fica on of accessible, non-invasive biomarkers to stra fy ... -
Targeted Polymer Macromolecules in the Treatment of Head and Neck Squamous Cell Carcinomas
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 14. 1. 2026Head and neck squamous cell carcinoma (HNSCC) represents a highly prevalent malignancy characterized by pronounced clinical, histopathological, and molecular heterogeneity. Despite advances in surgery, radiotherapy, and ... -
Inhibitors of rhomboid intramembrane proteases and their use in cell biology
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 17. 3. 2026Rhomboid serine proteases are highly conserved enzymes across all kingdoms of life. These intramembrane proteases are implicated in a wide range of cellular processes including cell signalling, quorum sensing, protein ... -
Identification and functional validation of novel mitochondrial disease genes
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 17. 3. 2026This dissertation focuses on the functional and molecular characterization of selected mitochondrial disorders and on the development of methods enabling non-invasive assessment of mitochondrial function. The first part ... -
The role of ultrasound in preoperative staging in patients with advanced ovarian cancer
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 24. 9. 2025Cíle studie: Primárním cílem bylo posoudit, zda specializované ultrazvukové vyšetření není horší než počítačová tomografie s podáním kontrastní látky (CT, contrast-enhanced computed tomography) a než celotělová magnetická ... -
Srovnání efektivity mechanické trombektomie aspirační technikou pomocí Penumbra ACETM katétru a stent retriever technikou pomocí SolitaireTM FR u pacientů s ischemickou cévní mozkovou příhodou
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 24. 3. 2025Mechanical thrombectomyis the standardtherapyinpatients withacute ischemic stroke (AIS) due to proximal cerebral vessel occlusion. The primaryaim of our study is a comparison of procedural efficacyof direct aspirationtechnique ... -
Charakterizace bazocelulárních a dlaždicových karcinomů hlavy a krku z hlediska exprese molekul s potenciálním prognostickým významem ve srovnání s normálními tkáněmi
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2026)Date of defense: 23. 3. 2026The incidence of head and neck cancer (HNC) is increasing worldwide and is a common cause of morbidity and mortality. Data from the Institute of Health Information and Statistics confirm this phenomenon in the Czech Republic. ... -
Role hypoxie a mikroprostředí v deregulaci apoptózy u agresivních lymfomů
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 18. 12. 2025Hypoxia plays key role in tumor biology impacting the growth, spread, and sensitivity to treatment. It typically develops in rapidly growing tumors and promotes aggressive behaviour of malignant cells. Non-Hodgkin lymphomas ...
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