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Nutrigenetic and nutrigenomic aspects of nutraceuticals in metabolic syndrome prevention
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 11. 9. 2025Metabolic syndrome (MetS) is a complex disorder characterized by insulin resistance. Its increasing prevalence worldwide highlights the need for effective strategies beyond pharmacotherapy to manage this condition. Among ... -
Clinical and neurophysiological markers in functional movement disorders
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 8. 9. 2025Functional motor disorders (FMD), previously referred to as conversion, psychogenic, or dissociative motor disorders, represent a complex and heterogeneous group of conditions characterized by a wide spectrum of abnormal ... -
Implementace metodiky ChildTalks+ zaměřené na podporu duševního zdraví dětí, jejichž rodiče trpí duševní poruchou.
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 24. 6. 2025This dissertation focuses on families in which parents suffer from mental disorders and raise minor children. These children represent a particularly vulnerable group at higher risk of developing and progressing their own ... -
Možnosti predikce některých těhotenských patologií
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 24. 9. 2025This dissertation focuses on pregnancy pathologies from genetic, clinical, and economic perspectives, aiming to improve the understanding of risk factors and optimize care for pregnant women throughout the entire course ... -
Development of hydrophilic polymer conjugates and molecular probes as antibody mimetics for biomedical applications
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 5. 9. 2025Recently developed synthetic polymer conjugates of N-(2-hydroxypropyl) methacrylamide (HPMA) in combination with low-molecular-weight ligands, called iBodies, alongside with small molecular probes, represent a promising ... -
Terapie plicní hypertenze u pacientů s pokročilým srdečním selháním a sníženou ejekční frakcí levé komory
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 25. 9. 2025Introduction: Combined pre- and post-capillary pulmonary hypertension (Cpc-PH) markedly worsens outcomes in advanced heart-failure patients with reduced ejection fraction (HFrEF). Experimental and clinical data suggest ... -
Vývoj počtu a charakteristik klientů a poskytovaných služeb v aplikační místnosti v Brně
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 10. 9. 2025Background: A drug consumption room is a specialized harm reduction service that provides a hygienic and safe environment for drug use under the supervision of trained professionals. The first injecting room in the Czech ... -
Virtualizace ve stomatologii
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 19. 5. 2025Fully digital workflows are beginning to dominate dental practices. The precision and accuracy of some intraoral scanners are not only sufficient but significantly surpass traditional impression techniques using plaster ... -
Patofyziologie a diferenciální diagnostika třesu
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 24. 3. 20251 Abstract The pathophysiology of tremor is diverse and, in some cases, not fully elucidated. In this thesis, we focus mainly on head tremor, which is a common symptom of essential tremor (ET), and cervical dystonia (CD). ... -
Porucha chování v REM spánku
Defence status: DEFENDED(Univerzita Karlova, 1. lékařská fakulta, 2025)Date of defense: 24. 3. 2025REM SLEEP BEHAVIOR DISORDER Abstract The dissertation focuses on REM sleep behavior disorder (RBD), a disease characterized by motor and vocal manifestations resulting from disrupted muscle atonia, which is otherwise ...
