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  • Tukové emulze v dlouhodobé parenterální výživě 

    Defence status: DEFENDED
    Ševela, Stanislav (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 25. 3. 2024
    The combination of intestinal failure and parenteral nutrition is a condition associated with mild chronic inflammation and organ injury, the most significant of which is hepatic injury. This crossover-controlled trial ...
  • Inhibition of TET-1 protein by iron chelators 

    Defence status: DEFENDED
    Whole item or its parts have restricted access until 26. 03. 2027
    Antonyová, Veronika (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 25. 3. 2024
    EN The objective of this work was to study novel synthetic iron chelators and to study their potential use in inhibition of TET1 (ten-eleven translocation methylcytosine dioxygenase 1) protein. Epigenetic mechanisms, such ...
  • Molekulární příčiny a mechanismy dědičných cholestáz a statiny indukované myopatie 

    Defence status: DEFENDED
    Neřoldová, Magdaléna (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 25. 3. 2024
    The discovery of the molecular basis of Rotor syndrome consisting in biallelic inactivating mutations in both SLCO1B1 and SLCO1B3 genes encoding hepatic transporters OATP1B1 and OATP1B3, together with the previously described ...
  • Charakterizace vrozených alterací genů podmiňujících vznik a prognózu dědičných forem vybraných nádorů dospělého věku 

    Defence status: DEFENDED
    Jelínková, Sandra (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 25. 3. 2024
    In my dissertation, I studied the genetic predisposition of selected types of cancer that have not been systematically studied in the Czech Republic. We used next-generation panel sequencing to identify germline pathogenic ...
  • Ateroskleróza a kardiovaskulární riziko u vybraných revmatických onemocnění. 

    Defence status: DEFENDED
    Oreská, Sabína (Univerzita Karlova, 1. lékařská fakulta, 2023)
    Date of defense: 24. 11. 2023
    Cardiovascular (CV) diseases due to atherosclerosis are the leading cause of morbidity and mortality worldwide. CV risk in rheumatic patients is caused by both traditional and non- traditional risk factors associated with ...
  • Vliv složení aterosklerotických plátů na rozvoj akutního koronárního syndromu 

    Defence status: DEFENDED
    Kopřiva, Karel (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 21. 3. 2024
    Thin fibrous cap atheroma with a high lipid content is the most common morphological substrate for acute coronary syndrome. Lipid content can be reliably determined by near infrared spectroscopy (NIRS) imaging. Optical ...
  • Mikrobiální transplantace a její vliv na průběh ulcerózní kolitidy 

    Defence status: DEFENDED
    Březina, Jan (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 21. 3. 2024
    The complex etiopathogenesis of idiopathic inflammatory bowel diseases (IBD) remains unclear, with one of the main suspected causes being the dysregulation of mucosal immunity in response to specific components of the gut ...
  • Steroidní metabolom a vícečetné těhotenství 

    Defence status: DEFENDED
    Černý, Andrej (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 21. 3. 2024
    Steroid hormones can be divided into 2 groups - intracellular and extracellular, depending on location of their activity. Intracellular ones influence expression of genes while acting as transcription factors. This so-called ...
  • Úloha sippingu v nutriční podpoře geriatrických pacientů 

    Defence status: DEFENDED
    Ondrová, Ellen (Univerzita Karlova, 1. lékařská fakulta, 2024)
    Date of defense: 23. 1. 2024
    Introduction: Malnutrition is a significant problem in old age. Malnutrition is present in 30 - 70 % of hospitalized elderly and its consequences are severe. Systematic screening and early treatment are essential to ensure ...
  • Závislost u osob s míšní lézí Dotazníkové šetření 

    Defence status: DEFENDED
    Egemová, Olga (Univerzita Karlova, 1. lékařská fakulta, 2023)
    Date of defense: 25. 1. 2023
    Background: In Czech Republic, the use of addictive substances in the general population is regularly evaluated. In people with spinal cord lesions, the issue of substance abuse is not sufficiently mapped. Difficulty to ...

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