Now showing items 1-20 of 31501

    • Transcriptomic profiling of the olfactory organs in mice. 

      Defence status: DEFENDED
      Grešš, Michal (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      Transcriptome studies are widely used to gain insights into tissue-specific biological processes. Although advances in sequencing technologies have greatly improved precision and throughput, the interpretation of read ...
    • The relationship between codon volatility and selection 

      Defence status: DEFENDED
      Kuniak, Adam (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      Codon volatility was proposed as a method to detect positive selection in the genome. It measures the probability that a single-nucleotide mutation in a codon will lead to a change in the encoded amino acid. This thesis ...
    • Development of tools for analysis and interpretation of docking study results 

      Defence status: DEFENDED
      Botková, Alexandra (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      Molecular docking is a widely used computational technique for predicting the preferred binding orientation and affinity of small molecules to protein targets. While docking programs such as AutoDock Vina provide ranked ...
    • Decoding functional representations from population activity in V1 recorded during sleep 

      Defence status: DEFENDED
      Jochman, Radoslav (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      This thesis investigates whether spontaneous neural activity during sleep enables more stable decoding of orientation preference (OP) maps in the human primary visual cortex compared to wakefulness. Using intracortical ...
    • Genetické příčiny periferních neuropatií a využití NGS a cloudových technologií v jejich diagnostice 

      Defence status: DEFENDED
      Horáková, Veronika (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      Hereditary peripheral neuropathies represent a heterogeneous group of genetically determined diseases that significantly affect the function of the peripheral nervous system. The main clinical manifestations are slowly ...
    • Alternative splicing analysis in single-cell RNA sequencing data 

      Defence status: DEFENDED
      Hanušová, Viktorie (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      Ischemic brain injury initiates complex molecular responses in microglia, the resident immune cells of the brain. This thesis investigates whether alternative splicing patterns in mouse microglia change after ischemic ...
    • Analýzy stabilních izotopů v bioarcheologickém výzkumu minulých populací střední a západní Evropy 

      Defence status: DEFENDED
      Vytlačil, Zdeněk (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      This summary form of the doctoral thesis (a monothematic set of publications) presents the results of isotopic research on mobility and diet in the contexts of Central and Western Europe, published in 8 scientific articles. ...
    • The Influence of Mutation Bias on Adaptive Evolution 

      Defence status: DEFENDED
      Jasková, Barbora (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      Title: The Influence of Mutation Bias on Adaptive Evolution Author: Barbora Jasková Department: Department of Cell Biology Supervisor: Dr. Hana Rozhoňová Abstract: In evolutionary biology, natural selection acts upon genetic ...
    • Inferring Phosphosite Functionality through Multi-Contextual Analysis 

      Defence status: DEFENDED
      Pulko, Ekaterina (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      Phosphorylation, one of the most studied post-translational modifications, regulates a multitude of cellular processes by affecting protein function and structure in various ways, and functional characterization of ...
    • Identifikace sekvenačních chyb v NGS vznikajících na podkladě sekvenčního kontextu, analytických postupů a mapovacích nástrojů 

      Defence status: DEFENDED
      Polák, Arnošt (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      DNA sequencing represents a fundamental pillar ofmoderndiagnostics for current needs of molecular medicine. Although today's next-generation sequencing (NGS) technologies enable efficient reading of the entire humangenome, ...
    • Identifikace nových indikací léčiv pomocí analýzy transkriptomu jednotlivých buněk 

      Defence status: DEFENDED
      Rýdlová, Magdaléna (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 17. 6. 2025
      De novo drug development represents an exceedingly complex, time-consuming, and expensive process. Drug repurposing, utilizing large-scale transcriptomic datasets, has emerged as a promising alternative, accelerating the ...
    • Kontaminace potravin perfluorovanými a polyfluorovanými látkami 

      Defence status: DEFENDED
      Talířová, Jasmína (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      Perfluorinated and polyfluorinated substances (PFAS) form a group of anthropogenic compounds that contain a strong carbon-fluorine bond. Due to this bond, they exhibit high stability, which has been utilized in various ...
    • Impact of snow reduction on decomposition and soil respiration 

      Defence status: DEFENDED
      Klárová, Anežka (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      The global decline in snow cover affects biochemical processes in soil, potentially leading to changes in the carbon cycle. This thesis describes global and regional snow cover trends and summarizes current knowledge and ...
    • Disturbance horských lesů vlivem lesního hospodaření a změn klimatu 

      Defence status: DEFENDED
      Smetana, Michal (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      In my work, I focused on describing the role of forest management and climate change on disturbances in montane temperate forests. Disturbances are an integral part of many ecosystems and play an important role in the ...
    • Globální a lokální příčiny ohrožení oceánských druhů žraloků: role abiotických, biotických a antropogenních faktorů 

      Defence status: DEFENDED
      Hrachová, Eliška (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      Sharks, a key predators, play an important role in maintaining the balance of food webs and regulating the populations of other marine organisms. Despite this, their populations have declined drastically in recent decades. ...
    • Ekologie rybích společenstev v okolí přehradních nádrží: struktura habitatů, migrace a potravní vztahy 

      Defence status: DEFENDED
      Štefko, Jiří (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      Dams significantly disrupt natural river ecosystems and change the character of streams. They affect not only the phycical and chemical proprties of watercourses, but also the structure andcomposition of fish and invertebrate ...
    • Význam ostrůvků neprodukčních biotopů pro ptáky v zemědělské krajině 

      Defence status: DEFENDED
      Lerlová, Michaela (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      Agricultural intensification and the associated loss of semi-natural habitats have contributed to a significant decline in biodiversity in agricultural areas in recent decades. Agricultural landscapes cover large areas in ...
    • Theoretical Investigation of Zeolites Using NMR: From DFT to Machine Learning 

      Defence status: DEFENDED
      Lei, Chen (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      Solid-state nuclear magnetic resonance (ssNMR) spectroscopy is a highly valuable tool for experimentally characterizing zeolites, due to its high sensitivity and the detailed structural insight it provides from the spectra. ...
    • Tvarová analýza aerosólových častíc emitovaných pohybom lodí 

      Defence status: DEFENDED
      Földvariová, Ema (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      The aim of this thesis was to identify the morphological features of sea spray aerosol particles and solid particles originating from ship engine combustion, and to highlight their differences depending on the mechanism ...
    • Mlha - kauzalita změn v jejím výskytu a její vliv na ekosystémy 

      Defence status: DEFENDED
      Veverková, Kateřina (Univerzita Karlova, Přírodovědecká fakulta, 2025)
      Date of defense: 16. 6. 2025
      The aim of this literature-based bachelor's thesis is to clearly summarize the importance of fog for various ecosystems using appropriately formulated research questions, and to identify the main long-term factors influencing ...

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