Faculty / university part collections

Recent Submissions

  • Synthesis of 7-aryl-7-deazapurines as potential inhibitors of MARK4 

    Defence status: DEFENDED
    Markušová, Katarína (Univerzita Karlova, Přírodovědecká fakulta, 2021)
    Date of defense: 13. 7. 2021
  • Use of ionic liquids for preparation of epoxy materials 

    Defence status: DEFENDED
    Rebei, Marwa (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 21. 6. 2024
    Epoxy resins represent an important category of thermosets widely as coatings, electronic encapsulants, matrices for composites, etc., due to their beneficial properties, such as strong adhesion, high chemical and electrical ...
  • Fotoaktivní chlorofylové nanočástice 

    Defence status: DEFENDED
    Ludačka, Pavel (Univerzita Karlova, Přírodovědecká fakulta, 2021)
    Date of defense: 12. 7. 2021
    Photoactive sulfonated and non-sulfonated polystyrene nanoparticles (NPs) with encapsulated THF extract from spinach (Spinacia oleracea) were prepared. The preparation of NPs is based on a simple nanoprecipitation method ...
  • Vliv nových derivátů chinazolinu na signální dráhy muskarinových receptorů 

    Defence status: DEFENDED
    Nelic, Dominik (Univerzita Karlova, Přírodovědecká fakulta, 2021)
    Date of defense: 12. 7. 2021
    The M2 and M3 subtypes of the muscarinic receptors are involved in smooth muscle contraction in the airways and lungs. Excessive activation of muscarinic receptors is associated with serious diseases such as asthma or ...
  • The characterization of Pseudomonas syringae biofilm and its interaction with antibacterial agents - biophysical approaches 

    Defence status: DEFENDED
    Whole item or its parts have restricted access until 21. 06. 2027
    Budil, Jakub (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 20. 6. 2024
    4 Abstract The objectives of this thesis are the application of Attenuated Total Reflectance Fourier Transform Infrared (ATR FT-IR) spectroscopy for the analysis of Pseudomonas syringae biofilms grown in a flow cell and ...
  • Modulation of nociceptive signalling on a spinal cord level under normal and pathological conditions 

    Defence status: DEFENDED
    Pontearso, Monica (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 20. 6. 2024
    Present pain therapies are often insufficient and poorly managed, mainly for neuropathic pain treatment. In the past years, research has provided a body of evidence on the association of nerve injury and inflammation with ...
  • Role of interaction between circadian and immune system in development of obesity and type 2 diabetes mellitus 

    Defence status: DEFENDED
    Honzlová, Petra (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 20. 6. 2024
    Disruptions within the circadian, metabolic, and immune systems contribute to the onset of metabolic illnesses, including type 2 diabetes. This doctoral thesis aimed to examine the mutual interactions between these three ...
  • Makrofágy selektivně rozpoznávají mechanicky způsobenou smrt melanomových buněk a spouštějí produkci CXCL10 

    Defence status: NOT DEFENDED
    Whole item or its parts have restricted access until 04. 06. 2027
    Otruba, Matúš (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 4. 6. 2024
    Melanoma represents a significant and often fatal form of cancer, with metastasis being a primary cause of cancer-related deaths. Immunotherapy aims to stimulate the immune system to eliminate tumors, but even when used ...
  • Epitranscriptomics and cardioprotective interventions 

    Defence status: DEFENDED
    Benák, Daniel (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 20. 6. 2024
    1 Ischemic heart disease stands as the foremost global cause of mortality. Myocardial ischemia results in damage to cardiomyocytes which can further lead to impaired heart function. However, the extent of ischemic injury ...
  • Linking Proteomes to Phenotypic Traits 

    Defence status: DEFENDED
    Jelínek, Tomáš (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    Proteins, as the main functional molecules of the cell, play a critical role in shaping phenotypic traits. This thesis investigates the application of proteomics data, obtained via LC-MS/MS, to understand the link be- tween ...
  • Bioinformatické prístupy k vyhodnoteniu frekvenčných populačných dát založených na sekvenčných polymorfizmoch DNA 

    Defence status: DEFENDED
    Milotová, Lujza (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    This thesis focuses on the problem of efficient management of data useful in DNA analysis, specifically data obtained from short tandem repeats in human DNA, which are of key importance in forensic analysis for the ...
  • Využití sekvenačních metod pro studium mikrobiálních komunit: (meta)genomové assembly a populační genomika u bakterií 

    Defence status: DEFENDED
    Vosyka, Michal (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    Sequencing of DNA from microbial communities enables, besides taxo- nomic profilling, study of intrapopulation genetic variability. Its description is a result of a computational analysis of sequencing data. This thesis ...
  • Vybrané metody analýzy dynamiky vnitrobuněčných struktur rostlinných buněk. 

    Defence status: DEFENDED
    Hrubá, Klára (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    This bachelor thesis focuses on the processes of acquiring and analysing image data in the field of microscopy, with an emphasis on the dynamics of intracellular structures in plant cells. The introductory section describes ...
  • Biophysical conditions triggering depolarization block in excitatory neurons. 

    Defence status: DEFENDED
    Tobiáš, Marek (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    Optogenetics is an increasingly popular neuronal stimulation technique used for study- ing neural circuits and controlling brain activity. However, when applied without suffi- cient knowledge, it can cause unintentional ...
  • Evaluation of programs for predicting the clinical significance of mutations in fibrinogen 

    Defence status: DEFENDED
    Gregušová, Anna (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    This bachelor's thesis compares the reliability of predicting the pathogenicity of mutations in the γ chain of fibrinogen using various predictive algorithms. The work is designed as a "blind study," where we investigate ...
  • Srovnání podobností hmotnostních spekter a struktur malých molekul 

    Defence status: DEFENDED
    Malíčková, Viktorie (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    Methods for measuring the similarity of mass spectra and the structures of small molecules are crucial for advancements in medicinal chemistry, pharmacology, and metabolomics. One commonly used method for comparing the ...
  • Analýza single cell dat za pomoci transformerů 

    Defence status: DEFENDED
    Preisler, Tomáš (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    This bachelor's thesis is focused on the use of machine learning and deep learning methods in an attempt to automate the annotation of cells based on their gene expression (single-cell data). In particular, it is focused ...
  • Detection of Similar Binding Sites in Protein Structure Databases 

    Defence status: DEFENDED
    Telčer, Jakub (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    The evaluation of protein-ligand binding site similarity is crucial in many fields, from drug repurposing trials to evolutionary studies. Current state-of-the- art methods achieve good results on the benchmarking datasets. ...
  • Cell-cell communication analysis in single-cell and spatial transcriptomics 

    Defence status: DEFENDED
    Laitl, Matouš (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 19. 6. 2024
    Intercellular communication orchestrates important tissue processes in all multicellular organisms. Recent advantages in single-cell and spatial transcriptomics unveil new possibilities in analysing cell-cell communica- ...
  • Analysis of mutual interactions of the human multifactor complex components in translation initiation 

    Defence status: DEFENDED
    Whole item or its parts have restricted access until 18. 06. 2027
    Prilepskaja, Terezie (Univerzita Karlova, Přírodovědecká fakulta, 2024)
    Date of defense: 17. 6. 2024
    A key task of translation initiation is to select a proper start codon. The start codon defines not only the position from which the protein translation is initiated but also the reading frame in which the protein sequence ...

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