Přírodovědecká fakulta
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Habilitační práce [26]
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Kvalifikační práce [13782]
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Kvalifikační práce do roku 2006 [0]
Theses until 2006
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Polymerní nosiče léčiv na bázi HPMA kopolymerů usnadňující směrování do pevných nádorů a pH-řízenou aktivaci léčiva
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 1. 4. 20192. Summary of the PhD. Thesis Introduction The use of synthetic polymer carriers of anticancer drugs represents a promising approach to cancer therapy. Conjugation of cýotoxic drugs with polymers may reduce their toxicity ... -
Ekologická a taxonomická struktura subaerických nárostů zelených řas na jehlicích nahosemenných dřevin
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 5. 2. 2019Aero-terrestrial algae form distinct biofilms on different natural and man-made surfaces. Their taxonomic diversity is considerable, but not yet fully studied, even though recent attention has been paid to it. The study ... -
Kardioprotektivní úloha adaptací na hypoxii a chlad: Konexin 43 a hexokináza 2
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 27. 3. 2019Ventricular arrhythmias are the main cause of death worldwide. An increased incidence of arrhythmias in the heart of mammals is accompanied by a remodeling of the cellular distribution gap between the channels of mainly ... -
Úloha adrenergní signalizace v adaptivním mechanismu kardioprotekce vyvolané chronickou hypoxií
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 27. 3. 2019Cardiovascular diseases are currently one of the most common causes of morbidity and mortality in the Western world. Adaptation to chronic hypoxia can contribute to the improvement of ischemic tolerance of myocardium but ... -
Factors interacting with bacterial RNA polymerase and their effect on the regulation of transcription initiation
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 26. 3. 2019(ENGLISH) The bacterial cell needs to regulate its gene expression in response to changing environmental conditions. RNA polymerase (RNAP) is the pivotal enzyme of this process and its activity is controlled by a number ... -
Bakteriální RNA polymeráza a molekuly ovlivňující její funkci
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 26. 3. 2019RNA polymerase (RNAP) transcribes DNA into RNA and is the only transcriptional enzyme in bacteria. This key enzyme responds to external and internal signals from the cell, resolves the intensity of transcription of individual ... -
Myš, potkan, krysa: prostor, pach a metody detekce
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 26. 3. 2019The coexistence of humans and rodents lasts from the beginnings of the history of agriculture. Many rodent populations accepted to synanthropic way of life and as commensals accompany human societies until today. In the ... -
Identifikace dědičných alterací predisponujících ke vzniku karcinomu prsu pomocí "nextgen" sekvenování.
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 25. 3. 2019Summary: Breast cancer (BC) is the most frequent cancer type in female population of Europe. Approximately 5 - 10 % accounts for its hereditary form which is characterized by high penetrance, early onset, risen recurrence ... -
Morfologie a aktivita vybraných lavinových drah v Hrubém Jeseníku a Králickém Sněžníku
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 28. 6. 2018The occurrence of avalanche paths is usually frequent in alpine environment, but it is also present in mid-mountains such as the High Sudetes. The submitted master thesis is focused on avalanche paths in the Eastern High ... -
Influence of bird schistosome Trichobilharzia regenti on haemocyte activity of lymnaeid snails
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 17. 9. 2018Gastropod molluscs are naturally exposed to various pathogens such as bacteria, or multicellular parasites that include digenetic trematodes (digeneans) which develop in snails. To combat these pathogens gastropods have ... -
Umlčování exprese transgenů v rostlinách bramboru a v buněčné linii tabáku BY-2
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 25. 6. 2018Accidental discovery of RNA interference in plants a few decades ago and its description by Fire et al. (1998) brought a real revolution in molecular biology and in many other branches of biology. Researchers have uncovered ... -
Fluidizace membrány alkoholy inhibuje signalizaci DesK-DesR u Bacillus subtilis
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 7. 6. 2018After cold shock, the Bacillus subtilis desaturase Des introduces double bonds into the fatty acids of existing membrane phospholipids. The synthesis of Des is regulated exclusively by the two-component system DesK/DesR; ... -
Hodnocení jednotlivých oborů biologie a oblíbenost přírodopisu u žáků 2. stupně ZŠ a nižšího gymnázia
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 18. 5. 2018Natural sciences are being less attractive for pupils in past few years. One of teachers'goals should be the effort to motivate pupils in all possible ways to study natural sciences. A whole range of factors, as sex, age, ... -
Prostorová kognice u potkanů: zpracování informace o pozici vzdálených objektů
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 21. 9. 2018Spatial behavior is widely studied to understand cognition and its neurophysiological substrate. Hippocampus plays a crucial role in many spatial tasks. It is unclear whether hippocampus is necessary for recognizing position ... -
Key factors in soil organic matter accumulation
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 15. 8. 2018Soil organic matter (SOM) is highly important for soil quality and the global carbon cycle. SOM content is influenced by a complex interplay of many different factors such as time, climate, parent material, vegetation, and ... -
Určení mocnosti eroze brněnského téglu
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 7. 6. 2018The thesis deals with an application of the geotechnical numerical back analysis and several other geotechnical conventional techniques in estimating the thickness of eroded sediments. Investigated strata is the Lower ... -
Širší souvislosti dopadu sluneční aktivity na úmrtnost podle příčin v České republice
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 11. 6. 2018The wider context of the impact of solar activity on mortality by cause in the Czech Republic Abstract The presented dissertation investigates the influence of extraterestrial phenomena, in the whole scope of their possible ... -
Účast alternativních sigma faktorů RNA polymerasy při regulaci exprese genů Corynebacterium glutamicum
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 20. 6. 2018Abstract Regulation of transcription by extracytoplasmic-function (ECF) sigma factors of RNA polymerase is an efficient way of cell adaptation to diverse environmental stresses. Amino acid- producing gram-positive bacterium ... -
Úloha fosfolipáz A2 v mechanismu kardioprotekce indukované adaptací na chronickou hypoxii
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 11. 6. 2018Cardiovascular diseases, particularly acute myocardial infarction, are the leading causes of death in developed countries including the Czech Republic. One of the ways to increase cardiac resistance against acute ... -
Vliv teploty na vznik arytmií během vývoje srdce
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 26. 3. 20185 Abstract: Aims: The main objective of this work was to analyze in detail the effects of acute temperature changes on the function of isolated chick embryonic heart in vitro in comparison with natural conditions in ovo. ...
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