Přírodovědecká fakulta
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Habilitační práce [32]
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Kvalifikační práce [14831]
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Kvalifikační práce obhajované před rokem 2006 [0]
Theses defended before year 2006
Recent Submissions
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Molecular mechanisms of mammalian circadian clocks, its sensitivity to constant light and aging
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 5. 2. 2020Many processes in mammalian body exhibit circadian rhythms. These rhythms are driven by an intricate system composed of the central pacemaker, suprachiasmatic nuclei (SCN) in the brain, which entrains the peripheral ... -
Development of electrochemical methods for study of antibacterial compounds in small volumes
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 5. 2. 2020Main goal of this Ph.D. thesis is to develop voltammetric methods for the electrochemical study of novel antimycobacterial compounds hydroxynaphthalene- carboxamides. Firstly, this study was focused on the miniaturization ... -
Vliv imunosuprese na buněčnou terapii u myšího modelu Alzheimerovy choroby
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 5. 2. 2020Alzheimer's disease is a chronic, progressive, neurodegenerative disease. It belongs to the most common type of dementia and worldwide it is statistically the fifth cause of mortality. The most common morphological markers ... -
Sedimenty šumavských jezer a jejich využití v paleoenvironmentálním výzkumu
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 5. 2. 2020Sediments of Bohemian Forest lakes are important natural archives. Their sedimentary record covers postglacial history of the lakes as well as history of natural processes in a wider region. It also documents local settlements ... -
Genová exprese v průběhu chronické myeloidní leukémie
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 5. 2. 2020 -
Role hipokampálních neuronů při tvorbě kognitivních schémat a prostorových vztahů vyššího řádu
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 5. 2. 2020The hippocampus is the key structure in formation of representations of space (cognitive maps) in rats. Formation of spatial representations of simple environments has been described in details, in this work we focused on ... -
Vliv přírodních látek na transkripční aktivitu jaderných a steroidních receptorů a expresi cytochromu P450 (CYP1A)
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 4. 2. 2020This work is based on two attached first authors' publications dealing with the effect of natural substances of plant origin on transcriptional activity of nuclear and steroid receptors and their action on cytochrome P450 ... -
Příprava myšího interleukinu 2 spojeného s monoklonální protilátkou S4B6
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 4. 2. 2020Interleukin 2 is a growth factor of T cells as well as other lymphocytes, such as NK, NKT cells, dendritic and mast cells, which ensure its expression and secretion. IL-2 regulates immune cell homeostasis and is used to ... -
Studium oxidační degradace tikagreloru
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 4. 2. 2020Ticagrelor is a platelet aggregation inhibitor drug, used for treatment of patients with acute coronary syndrome. The only active metabolite, a reverse blocator of P2Y12 adenosindiphosphate receptor, is produced by hepatic ... -
Využití elektrochemické oxidace v degradačních studiích abacaviru
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 4. 2. 2020The focus of this bachelor's thesis is the electrochemical degradation of abacavir. Abacavir is the active pharmaceutical ingredient of the medicine for human immunodeficiency virus (HIV). It was developed an electrochemical ... -
Populační genetika zimovišť druhového komplexu Pipistrellus pipistrellus
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020This thesis deals with two cryptic pipistrelle bat species, common pipistrelle (Pipistrellus pipistrellus) and soprano pipistrelle (Pipistrellus pygmaeus) living in sympatry in continental Europe. Although both species are ... -
Vliv typu diskriminační úlohy na rychlost a efektivitu diskriminačního učení vůči aposematické kořisti u ptačích predátorů
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020During the proces of learning to distinguish between edible and inedible prey, predators can encounter different types of prey either sequentially (one at a time) or simultaneously. Sequential as well as simultaneous ... -
Hematologická variabilita a její souvislost s gastroinstestinální mikrobiotou u papoušků (Psittaciformes)
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020Thousands of parrots all over the world suffer from illnesses and medical complications that can result from interactions between their immune system and bacteria in their digestive tract. The aim of this master's thesis ... -
Porovnávání kalibračních metod pro stanovení chininu v nápojích
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020The aim of this bachelor thesis is to compare three calibration methods used for determination of quinine in beverages performed by two instrumental methods. As the calibration methods, calibration curve method, standard ... -
Changes in domain organization of the plasma membrane in the stress response
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020MCC/eisosomes are yeast plasma membrane microdomains that respond to changes in both extracellular and intracellular conditions and activate important stress-related signaling pathways. In this study, we investigated the ... -
Pravidla buněčného škálování mozku u psů: Efekt domestikace a miniaturizace psích plemen
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020The process of domestication of the grey wolf (Canis lupus) resulted in more than 350 dog breeds attesting for an immense phenotypic plasticity of this species, reflected in the enormous variation of sizes, shapes and ... -
Rozpoznávání přirozených kategorií nepalatabilní kořisti ptačími predátory
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020Ability to categorize objects to classes and react to members of one class similarly is important for animals, for example to facilitate discrimination between palatable and unpalatable prey. Objects are typically categorized ... -
Evoluční a embryonální vývoj prechordální části hlavy
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020Rostral or the prechordal part of the vertebrate head is one of the key features that distinguishes us from other chordates. A part of this so-called New head is also a prechordal plate, also known as the prechordal or ... -
Genetic potential for methane metabolism in the Greenland subglacial ecosystem
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020Subglacial environments, located at the interface of glacier ice and bedrock, represent one of the major ecosystems associated with glaciers and ice sheets. This environment contains liquid water and underlying sediment ... -
Exploring the diversity of snow algae using polyphasic approach
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 3. 2. 2020Snow algae cause blooms in slowly melting snowfields in mountain and polar regions. Although they are excellent models for the study of life in extremely cold environments, their taxonomical diversity, geographical ...
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