Kvalifikační práce
Recent Submissions
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Role sestřihových faktorů v regulaci genové exprese - vztah sestřihu a transkripce v Saccharomyces cerevisiae
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 16. 3. 2020Transcription and pre-mRNA processing, e.g., splicing, occur at the same place and time in the context of chromatin. A growing amount of evidence supports the hypothesis that these processes are interconnected. Prp45/SKIP ... -
The Generation of Transgenic Huntington's Disease Miniature Pig
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 16. 3. 2020Huntingtons's disease (HD) is devastating neurodegenerative disorder manifesting by motor disturbances, cognitive decline and personal changes. The huge effort to find a cure for HD has brought several promising therapeutic ... -
Decisions in seed reproduction in plants
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 17. 3. 2020Seed reproduction is a key part of the life cycle of the most plant species. It allows for the dispersal of species in space and time and, thus, significantly affects dynamics of plant populations and communities. Seed ... -
Dispozice a metabolismus kanabinoidů
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 23. 4. 2020This thesis describes in the form of a commentary on own original publications research on the problems of cannabinoids, ie. phytocannabinoids and some synthetic cannabinoids, their pharmacokinetics and effects. The work ... -
Vzťah medzi zostrihom a posttranslačnými modifikáciami chromatínu u Saccharomyces cerevisiae
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 18. 9. 2018Protein Prp45, the yeast ortholog of the human transcription coregulator SNW1/SKIP, has been previously associated only with the regulation of pre-mRNA splicing. However, our laboratory found that protein Prp45 genetically ... -
Studium indukce intestinálních konjugačních enzymů doplňky stravy
(Univerzita Karlova, Přírodovědecká fakulta, 2013)Date of defense: 10. 6. 2013Cytochrome P450s (CYP) are enzymes, that play an important role in the metabolism of foreign compounds (e.g. drugs, carcinogens, pollutants) and they also participate in the metabolism of hydrophobic endogenic substrates ... -
Přírodovědná gramotnost a její rozvoj s využitím učebních úloh v chemii pro oblast ISCED 2
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 20. 9. 2018The objective of the dissertation was to assess the suitability of the scientific literacy development by using learning tasks in chemistry classes for ISCED 2. By comparing the learning tasks types in commercial workbooks ... -
Charakterizace nekanonické RNA polymerázy kódované lineárními plasmidy kvasinek
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 12. 3. 2020Transcription is the control point of gene expression. This process relies on protein complex of multisubunit RNA polymerases, which are extremely conserved among all cellular organisms. Transciption of extrachromosomal ... -
Molecular principles of translation reinitiation in mammals
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 12. 3. 2020Translation initiation is a multistep process resulting in the formation of the elongation-competent 80S ribosome at the AUG start codon of the mRNA to be translated into a polypeptide chain. This process is orchestrated ... -
Vliv sociálněgeografické exponovanosti a dalších faktorů na extenzifikační procesy využití krajiny
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 4. 3. 2020The main topic of the dissertation thesis is the evaluation of the influence of socio- geographical exposure and other factors (natural: altitude, inclination of slopes, productivity of land) on the extensification processes ... -
Role znalostních základen v regionálních inovačních systémech
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 4. 3. 2020The main goal of this work was to contribute to an understanding of the role of the knowledge bases in regional innovation systems and to identify whether the sizes of the different subsystems of regional innovation systems ... -
Sociogeografické determinanty rizikového užívania návykových látok u českých adolescentov
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 4. 3. 2020The thesis aims at the specific issues of health-related behaviour among the contemporary Czech youth, with particular emphasis on a socio-geographical dimension of the phenomena. In particular, it aims at identification ... -
Rhomboid family intramembrane proteases in prokaryotes: mechanism, substrate repertoires and biological functions in the Gram-positive bacterium Bacillus subtilis.
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 27. 2. 2020Rhomboid proteases are a class of serine intramembrane proteases, a large family of enzymes that catalyze the proteolytic cleavage of membrane proteins within their transmembrane regions, in the hydrophobic environment of ... -
Funkce stresových sigma faktorů RNA polymerasy SigD, SigE, SigH a SigM v transkripční regulační síti Corynebacterium glutamicum
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 27. 2. 2020Grampositive bacterium Corynebacterium glutamicum is an important industrial producer of amido acids and other metabolites. Its genome encodes 7 sigma (σ) subunits of RNA polymerase: primary factor σA , primary-like σB and ... -
Dynamics of species of fragmented dry grasslands at the landscape scale
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 25. 2. 2020Past extensive changes in land use have resulted in fragmentation of species habitats. Changes in landscape structure have provoked discussion about the prospects of species of fragmented habitats in the future agricultural ... -
Reprodukční strategie termita Silvestritermes minutus a její důsledky pro životní cyklus a ekologický úspěch
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 25. 2. 2020Mixed reproductive strategies are unique modes of reproduction, in which the organisms alternate sexual and asexual offspring production to benefit from both processes. In termites, such a strategy was first described in ... -
New leukocyte membrane adaptor proteins
(Univerzita Karlova, Přírodovědecká fakulta, 2018)Date of defense: 28. 11. 2018Membrane adaptor proteins are characterized by the lack of enzymatic activity and the presence of various interaction sites for other proteins and cellular membranes. They typically function as scaffolds connecting receptors ... -
Bird diversity and life-history patterns along gradients of productivity and its variation
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 19. 2. 2020Geographical variability in species richness and life-history strategies shows remarkable and well-documented patterns generated by various processes that have not yet been fully revealed. However, the pronounced correlation ... -
Lidská onemocnění způsobená zárodečnými mutacemi Hedgehog signální dráhy
(Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 17. 2. 2020The Hedgehog signalling pathway is involved in regulation of differentiation of embryonic cells, in body patterning, in development of brain, bone, muscle, gastrointestinal tract, lungs, and in maintenance and regeneration ... -
Dopad regionálnej zmeny klímy na hydrologický režim s ohľadom na extrémne situácie
(Univerzita Karlova, Přírodovědecká fakulta, 2019)Date of defense: 10. 9. 2019Investigation of changes in the rainfall-runoff regimes of rivers and its extremes has become more important especially in the context of ongoing and future climate changes. The main aim of this study is to investigate the ...
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