Now showing items 21-40 of 29669

    • Congenital disorders of glycosylation and their impact on cellular and energetic metabolism 

      Defence status: RECOGNIZED
      Whole item or its parts have restricted access until 01. 02. 2027
      Rychtárová, Lucie (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 1. 2. 2024
      Inherited disorders of glycosylation (CDG) are a large group of more than 160 types of metabolic disorders caused by genetic defects that lead to impaired glycan biosynthesis and modification. The lipid dolichol plays an ...
    • Molekulárně-genetická analýza karcinomů štítné žlázy u dětských a dospívajících pacientů 

      Defence status: DEFENDED
      Bulanová, Barbora (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 1. 2. 2024
      Thyroid nodules are rare in pediatric and adolescent patients, but they are at greater risk of malignancy than adult patients. Thyroid carcinomas are the most common endocrine malignancy and their incidence is increasing. ...
    • Strategie práce s obecně geografickou mapou jako zdrojem informací 

      Defence status: RECOGNIZED
      Trokšiar, David (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 7. 2. 2024
      The main topic of this thesis are map skills, and the key point of interest are strategies used for map analysis. General reference map was found as a suitable map given its frequent use in the school atlases. The main ...
    • Comparison of immunomodulatory properties of mesenchymal stem cells and Sertoli cells 

      Defence status: DEFENDED
      Porubská, Bianka (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 31. 1. 2024
      Cell therapies are increasingly considered in preclinical studies and in the future of medicine. The main cell type investigated in this manner is mesenchymal stem cells (MSCs), because of their strong immunomodulatory ...
    • Vybrané laboratorní metody ve výuce chemie: videonávody 

      Defence status: DEFENDED
      Cosentino, Nikola (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 31. 1. 2024
      The bachelor's thesis focuses on the teaching of laboratory methods at primary and secondary schools and its support with educational videos. A comparison of framework education programs and school education programs ...
    • Role asparagin syntetázy v leukemických buňkách 

      Defence status: DEFENDED
      Šafrhansová, Lucie (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 31. 1. 2024
      This thesis focuses on the detection of mutations in the enzyme asparagine synthetase on leukemia cell metabolism and the role of this enzyme in the context of L-asparaginase- based chemotherapy. The experimental part of ...
    • Diversity of CD8+ T-cell adaptive immune responses 

      Defence status: DEFENDED
      Paprčková, Darina (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 31. 1. 2024
      CD8+ T cells are specialized immune cells that recognize and eliminate infected or malignant cells by directly attacking and destroying them. Moreover, their ability to form long-lasting memory responses ensures a rapid ...
    • Signaling pathways in T-cell-mediated immunity 

      Defence status: DEFENDED
      Janušová, Šárka (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 31. 1. 2024
      The immune system provides protection of the host against pathogens, and tumor cells while maintaining a tolerance to self-tissues. T cells are important players in orchestrating the immune response. Helper T cells navigate ...
    • Funkcionalizované hypersesíťované porézní polyacetyleny 

      Defence status: RECOGNIZED
      Havelková, Lucie (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 13. 2. 2024
      An atom-economic one-step chain-growth coordination homopolymerization providing high yields of functionalized hyper-cross-linked polyacetylenes with permanent micro/mesoporous texture and specific surface area up to 1062 ...
    • Catalytic and photochemical cycloadditions of alkynes 

      Defence status: DEFENDED
      Fadeev, Aleksandr (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 30. 1. 2024
      Novel approaches to utilizing alkynes in transition metal-catalyzed [2+2+2] cycloadditions and photochemical [2+2] cycloadditions were investigated with respect to the potential applications of these transformations. First, ...
    • Design, synthesis and evaluation of novel inhibitors of class II PI4Ks and RIPK2/3 kinases 

      Defence status: DEFENDED
      Misehe, Mbilo (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 29. 1. 2024
      Synthetic kinase inhibitors are chemical tools to investigate cellular roles of kinase enzymes and, potentially, find new treatments for various diseases that are connected with their dysregulated expressions and activities. ...
    • Reakce ptačích predátorů na automimikry u ploštic z čeledi Lygaeidae 

      Defence status: DEFENDED
      Stránská, Anna (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 29. 1. 2024
      Automimicry, or intraspecific variation in defence mechanisms in aposematic prey, is very common in nature. Especially in chemically protected prey. This study contains two experiments. The first experiment investigated ...
    • Effects of gluten-free diet on immune parameters in Parkinson's disease 

      Defence status: NOT DEFENDED
      Jandová, Mônica (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 29. 1. 2024
      Tato studie zkoumá možné, i malé, vlivy bezlepkové diety v porovnání se standardní dietou na rozvoj Parkinsonovi nemoci s využitím 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinem (MPTP) indukovaném myším modelu Parkinsonovi ...
    • Karyotypová variabilita evropských štírů čeledi Euscorpiidae 

      Defence status: DEFENDED
      Byronová, Markéta (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 29. 1. 2024
      Current cytogenetic knowledge of the Euscorpiidae family is known for only 14 species. This work presents cytogenetic analysis of other selected species of this family. Variability in the diploid number of chromosomes and ...
    • Společenství parazitoidů dvou druhů drobných motýlů žijících na chmelu otáčivém 

      Defence status: DEFENDED
      Hovorka, Tomáš (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 29. 1. 2024
      Interactions between parasitoids, phytophagous insects and their host plants play one of the crucial role in the trophic relationships of terrestrial food webs. According to current knowledge, more than half of all known ...
    • Nestrannost a hodnotové vzdělávání při výuce politické geografie na středních školách v Česku: Příklad války v Jugoslávii 

      Defence status: DEFENDED
      Gáthy, Zuzana (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 26. 1. 2024
      According to the Education Act the education is supposed to be apolitical, but at the same time the teacher is supposed to educate students about values. The question is how far it is better to remain impartial in order ...
    • Hodnocení výsledků a kvality testu online okresního kola kategorie D Zeměpisné olympiády 2020/21 

      Defence status: DEFENDED
      Filipová, Diana (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 26. 1. 2024
      The thesis deals with the analysis of tests of category D (secondary schools) of the district round of the 23rd year of the Geography Olympiad and the evaluation of their quality. In the theoretical part the concept of ...
    • Členění oblasti Šumavy z hlediska silných srážek 

      Defence status: DEFENDED
      Králová, Kateřina (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 26. 1. 2024
      Divison of the region of the Šumava/Böhmerwald Mts. in terms of heavy precipitation Abstract This thesis deals with the spatial and temporal distribution of heavy precipitation in the Šumava region. The first part of the ...
    • Faktory přispívající k adaptaci lidského patogenu Bordetella pertussis na stresové podmínky 

      Defence status: DEFENDED
      Hejnarová, Václava (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 26. 1. 2024
      The role of bivalent metals as cofactors in various enzymes is essential for all domains of life. Their importance can be seen in interactions of hosts with patogens such as Bor- detella pertussis. This bacterium has several ...
    • Zelené cenobiální řasy čeledi Hydrodictyaceae, jejich fenotypová plasticita a využití v ekologii a paleoekologii 

      Defence status: DEFENDED
      Zavadilová, Kateřina (Univerzita Karlova, Přírodovědecká fakulta, 2024)
      Date of defense: 26. 1. 2024
      Algae of the family Hydrodictyaceae attract our attention because of their unusual appearance. They belong to the order Sphaeropleales in the class Chlorophyceae. This family includes the coenobial algae, traditionally ...

      © 2017 Univerzita Karlova, Ústřední knihovna, Ovocný trh 560/5, 116 36 Praha 1; email: admin-repozitar [at] cuni.cz

      Za dodržení všech ustanovení autorského zákona jsou zodpovědné jednotlivé složky Univerzity Karlovy. / Each constituent part of Charles University is responsible for adherence to all provisions of the copyright law.

      Upozornění / Notice: Získané informace nemohou být použity k výdělečným účelům nebo vydávány za studijní, vědeckou nebo jinou tvůrčí činnost jiné osoby než autora. / Any retrieved information shall not be used for any commercial purposes or claimed as results of studying, scientific or any other creative activities of any person other than the author.

      DSpace software copyright © 2002-2015  DuraSpace
      Theme by 
      @mire NV