Stanovení perzistentních organohalogenových polutantů metodou GC/MS/MS
Determination of persistent organohalogen pollutants using GC/MS/MS methods
dissertation thesis (DEFENDED)
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http://hdl.handle.net/20.500.11956/95741Identifiers
Study Information System: 198280
Collections
- Kvalifikační práce [20084]
Author
Advisor
Referee
Ševčík, Jiří
Matisová, Eva
Faculty / Institute
Faculty of Science
Discipline
Analytická chemie
Department
Department of Analytical Chemistry
Date of defense
28. 6. 2006
Publisher
Univerzita Karlova, Přírodovědecká fakultaLanguage
Czech
Grade
Pass
Conclusions o MSiMS methods for analysis of PCDD/Fs, PCBs, OCPs, and PBDES were develoPed o GC separations were optimized for MS/MS detection methods o GC/MS/MS optimized methods were validated. o Limits of quantification at level 0.1 - I pg/pl were achieved. o Linear response over four orders of magnitude was achieved except for some OCPs. o The selectivity of methods is better or comparable with a reference HRMS method' o Cost of GC/MS/MS analysis is significantly lower comPared to GC/HRMS o Developed methods were successfully applied for o Human blood, milk and adipose tissue analysis o Studies of de novo synthesis and destruďion of halogenated POP o In vitro study of PCB accumulation in human cells o List of application is enclosed Page 12