Surgical treatment of diabetic macular edema
Chirurgická léčba diabetického makulárního edému
dizertační práce (OBHÁJENO)
Zobrazit/ otevřít
Trvalý odkaz
http://hdl.handle.net/20.500.11956/3369Identifikátory
SIS: 133444
Kolekce
- Kvalifikační práce [4497]
Autor
Vedoucí práce
Oponent práce
Korda, Vladimír
Boguszaková, Jarmila
Fakulta / součást
1. lékařská fakulta
Obor
-
Katedra / ústav / klinika
Oční klinika 1. LF UK a VFN v Praze
Datum obhajoby
23. 3. 2006
Nakladatel
Univerzita Karlova, 1. lékařská fakultaJazyk
Angličtina
Známka
Prospěl/a
Diabetic macular edema is the most common cause of visual impairment in diabetic patients. Precise pathophysiology of diabetic macular edema is unclear and seems to be multifactorial and includes pericyte loss, microaneurysm formation, basement membrane thickening and focal closure of the capillary bed, vitreomacular traction, and ultimately breakdown of the blood-retinal barrier with increased vascular permeability. Risk factors for clinical significant diabetic macular edema are hyperglycemia, hypertension, hyperlipidemia, duration of diabetes, and pregnancy. The increasing number of individuals with diabetes worldwide suggests that diabetic macular edema will continue to be major contributors to vision loss and associated functional impairment in the working-age population of most developed countries. Although eyes with diffuse macular edema carry a particularly poor prognosis despite laser photocoagulation, laser treatment is still the first choice of treatment for diabetic macular edema as it is safety and less invasive that other surgical options. Diffuse diabetic macular edema is characterized by diffuse leakage from extensive areas of the posterior retinal capillary bed, a scarcity of hard exudates, and often the formation of cystoid spaces. Focal macular edema, in contrast, is characterized by...