Cathepsins B of the bird schistosome, Trichobilharzia regenti
Katepsiny B ptačí schistosomy Trichobilharzia regenti
dizertační práce (OBHÁJENO)
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Celý dokument nebo jeho části jsou nepřístupné v souladu s čl. 18a odst. 7 Studijního a zkušebního řádu Univerzity Karlovy v Praze ve spojení s čl. 3 opatření rektora č. 39/2009.
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http://hdl.handle.net/20.500.11956/26215Identifikátory
SIS: 82911
Kolekce
- Kvalifikační práce [19966]
Autor
Vedoucí práce
Oponent práce
Grevelding, Christoph G.
Horn, Martin
Fakulta / součást
Přírodovědecká fakulta
Obor
Parazitologie
Katedra / ústav / klinika
Katedra parazitologie
Datum obhajoby
30. 8. 2010
Nakladatel
Univerzita Karlova, Přírodovědecká fakultaJazyk
Angličtina
Známka
Prospěl/a
Klíčová slova (česky)
katepsin, peptidáza, parazit, Trematoda, schistosomyKlíčová slova (anglicky)
cathepsin, peptidase, parasite, Trematoda, schistosomes1. Overview Schistosomes have achieved first position among parasitic helminths, because some of them are the etiological agents of a serious human parasitic disease, schistosomiasis, which affects over 200 million people in tropical and subtropical countries (WHO, 2001). Other schistosomatids, such as the bird flukes of the genus Trichobilharzia, have also implications for human health. Although they can mature only in specific hosts (birds), their invasive larvae - cercariae - are able to penetrate also human skin due to chemical signals similar to those present on bird skin (Haas and van de Roemer 1998). Repeated infections result in an inflammatory reaction of the skin called cercarial dermatitis. Due to the increasing number of outbreaks all around the world, cercarial dermatitis is cons disease (Kolářová 2007idered as re-emerging ; Larsen et al. 2004). Among schistosomes, Trichobilharzia regenti is the only species described so far having a unique migration route within vertebrate hosts: after penetration of the skin, the invasive larvae enter peripheral nerves and continue via the spinal cord and central nervous system to the nasal cavity of birds, causing neuromotor disorders or paralyses of birds and even experimental mammals (Hrádková...