Analysis of diaphragm movement during its postural function using m-mode ultrasonography in conjunction with spirometry Abstract The diaphragm is a principal inspiratory muscle that, together with the abdominal wall muscles, ...

Based on retrospective analysis combined with assessment of histopathological changes the study aimed to determine risk factors of conduit failure, evaluate long-term conduit survival, propose potential ways to improve ...

Rare diseases are a diverse group of mostly inherited diseases with a very low prevalence of less than 1/2000 in the population. Identification of new genetic variants associated with these specific diseases is important ...

The thesis describes the application of cultured bone marrow stem cells in the therapy of focal chondral defect of the knee joint. In the experimental part of the work, the goal was to quantitatively and qualitatively ...

1 Adverse events of biologic therapy in psoriasis Abstract This doctoral thesis focuses on psoriasis vulgaris and its therapy, especially biologic agents and their safety profiles. The objectives of this research were to ...

Associations of morphometric and metabolic biomarkers with cognitive impairment in Alzheimer's disease and Lewy body dementias Abstract Dementia has become one of the major health care and socio-economic challenges. ...

Type 1 diabetes is characterized by chronic hyperglycaemia leading to life-threatening complication. The pathogenetic mechanism of T1D is the abnormal immune reaction destroying β-cell mass in pancreas. The current therapy ...

The clinical relevance of immunogenic cell death-associated signaling and molecules in cancer therapy The capacity of cancer cells to induce anticancer immune responses relies on multiple factors, including the antigenic ...

Two regions within the cannabinoid receptor 1 (CB1R) C-tail, 425 SMGDS429 and 460 TMSVSTDTS468 , contain clusters of serine and threonine residues that can be phosphorylated and collectively play an essential role in the ...

- Part I (clinical study) Background: Patients with injuries to multiple organs or organ systems are in a serious risk of shock, multiorgan failure and death. Although there are scoring systems available to assess the ...

Unstable atherosclerotic carotid plaque diagnosis and influence on cerebral hemodynamics ABSTRACT Atherosclerosis of carotid arteries belongs to most important risk factors of stroke especially if unstable plaques are ...

The morphology of the craniofacial complex is prone to alterations resulting from a wide range of external factors. In the first part of the presented thesis, we analysed the influence of slow long- term changes of the ...

Perinatal insult may lead to a permanent impairment of brain function resulting in the development of epilepsy. Status epilepticus (SE) in immature rats leads to hippocampal hyperexcitability. The functional and morphological ...

In preclinical research on Alzheimer's disease pharmacotherapy, attention is paid to multipotent compounds, enabling intensification of the effect by targeting multiple pathophysiological mechanisms. The aim of the thesis ...

Introduction: The subject of this thesis were two dynamic diagnostic methods of the musculoskeletal system: dynamic ultrasound examination and instrumental objectification of postural functions (measurement of the pressure ...

Anatomy of the human uterus vascular supply with respect to uterus transplantation Abstract This dissertation thesis deals with the blood supply of the human uterus and its relevance to uterus transplantation. The first ...

Introduction: Hypertrophic cardiomyopathy (HCM) is characterised by marked heterogeneity both in phenotype and genotype. One of the main objectives in medical care is early HCM diagnosis and prevention of cardiovascular ...

The adoptive cellular immunotherapy (ACI) based on ex vivo produced T cells is a modern treatment modality of cancer. However, the ex vivo production of T cells with high therapeutic efficacy is far to be well established. ...

One-trial association task as a basic biological model of episodic memory in rats Abstract A very important structure in the animal and human brain is the hippocampus. The study one of its many functions, episodic memory, ...

The skin is the largest organ of a human body with a crucial role in the maintenance of homeostasis; therefore any extensive skin injury leads to severe complications. Since the application of auto-, allo- and xeno-grafts ...

Pulmonary hypertension is a group of diseases characterized by increased mean pulmonary artery pressure. Especially in group 2, which is associated with heart disease and is the most prevalent of all types, and in group ...

Connective tissues are characterized by significant volume of extracellular matrix. Their main role is to provide a mechanical support and protection to other body organs. This thesis is focused on regeneration of bone, ...

Spinal cord injury is a serious trauma and despite intensive research there is still no effective treatment for patients. The aim of this thesis is to study new possibilities of spinal cord injury therapy in animal models. ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by degradation of motoneurons (MN). No effective treatment is currently available. Cellular therapy is considered to be a promising experimental ...

Identifikační záznam: SHEARDOVA, Kateřina. The Design and Conduct of the study of aging, and MCI within International Clinical Research Centre in Brno, Czech Republic, with the emphasis on the life style factors. Praha, ...

Epilepsy, as the most common chronic neurological disease, affects a significant part of population (0.5-1%). Drug resistant epilepsy has a significant negative effect on the quality of life, psychiatric comorbidities, ...

The presented dissertation deals with prognostic factors influencing a favorable postoperative outcome in patients undergoing surgical treatment of epilepsy and the possibilities of improving the methods used in the ...

Detection of early pathophysiological changes of breathing in children with chronic respiratory disease MD. Vaclav Koucky - Ph.D. thesis Abstract Introduction: Currently, there are different methods for infant pulmonary ...

Introduction: Immunochemical methods have significant importance in biomedical research. The benefit of immunochemical methods is their high sensitivity and accuracy. The aim of the work was to use immunochemical methods ...