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Evoluce a vývoj očí: při studiu medúzy a myši
dc.creatorRůžičková, Jana
dc.date.accessioned2018-04-18T14:07:58Z
dc.date.available2018-04-18T14:07:58Z
dc.date.issued2009
dc.identifier.urihttp://hdl.handle.net/20.500.11956/95909
dc.description.abstractI. AIMS OF THE STUDY Vision is one of the most crucial senses in higher vertebrates and perhaps the most important sense for humans. The eye morphogenesis has been studied for a long time and especially in the last two decades to address the function of individual genes duing eye development became one of the most interesting topic. Although most of our knowledge about the genetic program underlying eye formation comes from vertebrates, valuable new information about eye evolution has recently been obtained by studies of cnidaria. Therefore elucidation of the biological role and function of eye components of jellyfish Tripedalia cystophora will enhance our knowledge of specific aspects of both eye evolution and development. Specific aims of my PhD thesis were as follows: 1. to describe a new crystallin gene in jellyfish Tripedalia cystophora with respect to the evolution of its regulatory sequences; 2. to characterize genes required for the assembly of camera-type eyes in jellyfish Tripedalia cystophora; 3. to study the role of Wnt/β-catenin during lens induction and formation by employing a new mouse tissue-specific Cre-line; 4. to investigate the functional properties of jellyfish PaxB by expressing it in the developing lens and retina of transgenic mice. 6en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, Přírodovědecká fakultacs_CZ
dc.titleEye evolution and development: an insight from jellyfish and mouseen_US
dc.typerigorózní prácecs_CZ
dcterms.created2009
dcterms.dateAccepted2009-07-08
dc.description.departmentDepartment of Cell Biologyen_US
dc.description.departmentKatedra buněčné biologiecs_CZ
dc.description.facultyPřírodovědecká fakultacs_CZ
dc.description.facultyFaculty of Scienceen_US
dc.identifier.repId175781
dc.title.translatedEvoluce a vývoj očí: při studiu medúzy a myšics_CZ
thesis.degree.nameRNDr.
thesis.degree.levelrigorózní řízenícs_CZ
thesis.degree.disciplineCellular and Developmental Biologyen_US
thesis.degree.disciplineBuněčná a vývojová biologiecs_CZ
thesis.degree.programBiologyen_US
thesis.degree.programBiologiecs_CZ
uk.faculty-name.csPřírodovědecká fakultacs_CZ
uk.faculty-name.enFaculty of Scienceen_US
uk.faculty-abbr.csPřFcs_CZ
uk.degree-discipline.csBuněčná a vývojová biologiecs_CZ
uk.degree-discipline.enCellular and Developmental Biologyen_US
uk.degree-program.csBiologiecs_CZ
uk.degree-program.enBiologyen_US
thesis.grade.csProspělcs_CZ
thesis.grade.enPassen_US
uk.abstract.enI. AIMS OF THE STUDY Vision is one of the most crucial senses in higher vertebrates and perhaps the most important sense for humans. The eye morphogenesis has been studied for a long time and especially in the last two decades to address the function of individual genes duing eye development became one of the most interesting topic. Although most of our knowledge about the genetic program underlying eye formation comes from vertebrates, valuable new information about eye evolution has recently been obtained by studies of cnidaria. Therefore elucidation of the biological role and function of eye components of jellyfish Tripedalia cystophora will enhance our knowledge of specific aspects of both eye evolution and development. Specific aims of my PhD thesis were as follows: 1. to describe a new crystallin gene in jellyfish Tripedalia cystophora with respect to the evolution of its regulatory sequences; 2. to characterize genes required for the assembly of camera-type eyes in jellyfish Tripedalia cystophora; 3. to study the role of Wnt/β-catenin during lens induction and formation by employing a new mouse tissue-specific Cre-line; 4. to investigate the functional properties of jellyfish PaxB by expressing it in the developing lens and retina of transgenic mice. 6en_US
uk.file-availabilityV
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, Přírodovědecká fakulta, Katedra buněčné biologiecs_CZ


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