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Nádorový supresor HIC1- nový inhibitor signalní dráhy Wnt
dc.contributor.advisorKořínek, Vladimír
dc.creatorPospíchalová, Vendula
dc.date.accessioned2017-04-10T14:22:40Z
dc.date.available2017-04-10T14:22:40Z
dc.date.issued2008
dc.identifier.urihttp://hdl.handle.net/20.500.11956/5453
dc.description.abstract1. ABSTRACT In all metazoan organisms Wnt ligands regulate various developmental and physiological processes during embryogenesis and also in adult tissues. Moreover, deregulation in Wnt-related signalling is associated with several human disorders including cancer. In the so-called canonical pathway, activation of the Wnt receptor complex Frizzled/LRP triggers a complex network of molecular events that ultimately lead to the stabilization of β-catenin and formation of TCF/β- catenin heterodimers in the nucleus. These protein complexes drive expression of a specific set of genes that control the cell fate decision. The Wnt pathway is tightly regulated by several mostly negative feedback loops involving scores of extracellular, cytoplasmic or nuclear proteins. Recently, we have identified tumour suppressor Hypermethylated in cancer 1 (HIC1) as a negative modulator of canonical Wnt signalling. The HIC1 gene encodes a BTB/POZ-zinc finger transcriptional repressor. Interestingly, the HIC1-dependent repression of the TCF/β-catenin- dependent genes is not mediated by direct association of HIC1 with the regulatory regions of the Wnt-responsive genes but rather by a sequestration of TCF/β-catenin complexes to the nuclear speckle-like structures - the HIC bodies. These data indicate quite a pleiotropic role of HIC1...en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, Přírodovědecká fakultacs_CZ
dc.titleTumour Suppressor HIC1 - a novel inhibitor of Wnt Signallingen_US
dc.typediplomová prácecs_CZ
dcterms.created2008
dcterms.dateAccepted2008-05-28
dc.description.departmentDep. of Physiology and Develop. Biology (obsolete)en_US
dc.description.departmentKatedra fyziol. živočichů a vývoj. biol. (zrušena)cs_CZ
dc.description.facultyPřírodovědecká fakultacs_CZ
dc.description.facultyFaculty of Scienceen_US
dc.identifier.repId34631
dc.title.translatedNádorový supresor HIC1- nový inhibitor signalní dráhy Wntcs_CZ
dc.contributor.refereeFilipp, Dominik
dc.identifier.aleph001008674
thesis.degree.nameMgr.
thesis.degree.levelnavazující magisterskécs_CZ
thesis.degree.disciplineImmunologyen_US
thesis.degree.disciplineImunologiecs_CZ
thesis.degree.programBiologiecs_CZ
thesis.degree.programBiologyen_US
uk.thesis.typediplomová prácecs_CZ
uk.taxonomy.organization-csPřírodovědecká fakulta::Katedra fyziol. živočichů a vývoj. biol. (zrušena)cs_CZ
uk.taxonomy.organization-enFaculty of Science::Dep. of Physiology and Develop. Biology (obsolete)en_US
uk.faculty-name.csPřírodovědecká fakultacs_CZ
uk.faculty-name.enFaculty of Scienceen_US
uk.faculty-abbr.csPřFcs_CZ
uk.degree-discipline.csImunologiecs_CZ
uk.degree-discipline.enImmunologyen_US
uk.degree-program.csBiologiecs_CZ
uk.degree-program.enBiologyen_US
thesis.grade.csVýborněcs_CZ
thesis.grade.enExcellenten_US
uk.abstract.en1. ABSTRACT In all metazoan organisms Wnt ligands regulate various developmental and physiological processes during embryogenesis and also in adult tissues. Moreover, deregulation in Wnt-related signalling is associated with several human disorders including cancer. In the so-called canonical pathway, activation of the Wnt receptor complex Frizzled/LRP triggers a complex network of molecular events that ultimately lead to the stabilization of β-catenin and formation of TCF/β- catenin heterodimers in the nucleus. These protein complexes drive expression of a specific set of genes that control the cell fate decision. The Wnt pathway is tightly regulated by several mostly negative feedback loops involving scores of extracellular, cytoplasmic or nuclear proteins. Recently, we have identified tumour suppressor Hypermethylated in cancer 1 (HIC1) as a negative modulator of canonical Wnt signalling. The HIC1 gene encodes a BTB/POZ-zinc finger transcriptional repressor. Interestingly, the HIC1-dependent repression of the TCF/β-catenin- dependent genes is not mediated by direct association of HIC1 with the regulatory regions of the Wnt-responsive genes but rather by a sequestration of TCF/β-catenin complexes to the nuclear speckle-like structures - the HIC bodies. These data indicate quite a pleiotropic role of HIC1...en_US
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, Přírodovědecká fakulta, Katedra fyziol. živočichů a vývoj. biol. (zrušena)cs_CZ
dc.identifier.lisID990010086740106986


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