Přínos stanovení cytokinů u zánětlivých pooperačních komplikací
Benefit of assesment of cytokines in inflammatory postoperative complications
dizertační práce (OBHÁJENO)
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Trvalý odkaz
http://hdl.handle.net/20.500.11956/4952Identifikátory
SIS: 94335
Kolekce
- Kvalifikační práce [4458]
Autor
Vedoucí práce
Oponent práce
Vokurka, Martin
Adamec, Miloš
Fakulta / součást
1. lékařská fakulta
Obor
-
Katedra / ústav / klinika
Institut klinické a experimentální medicíny
Datum obhajoby
22. 11. 2006
Nakladatel
Univerzita Karlova, 1. lékařská fakultaJazyk
Čeština
Známka
Prospěl/a
Infection and the resulting sepsis continue to be important causes of morbidity in surgical patients. Cytokine network causes activation of neutrophils and vascular endothelium with increased upregulation of adhesion molecules, setting at a train of pathogenic inflammatory reactions in the host. Increased concentrations of inflammatory cytokines observed in the initial phase of postoperative complications have a great significance in forecasting a potentially fatal outcome of the disease and can be used for an early diagnosis of systemic complications.Prospective, clinical trial. Levels of cytokines, procalcitonin (PCT), leptin and acute phase proteins (APP) were measured before and after the operation (planned resection of colorectal cancer) and compared with levels in sepsis. Cytokine levels were measured by ELISA method. APP were estimated by nephelometric analysis.PCT was measured by immunoluminometric analysisDuring the first 24 h after the planned resection of colorectal cancer there was a significant increase in serum concentration of interleukin (IL)-6 which declined in next 48 to 72 h. Serum concentration of tumor necrosis factor (TNF)was the highest between 18 to 24 h after the operation. IL-1 had a stable serum concentration without significant elevation. Serum concentration of IL-8 rose after 36...