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Chirurgická léčba pokročilé osteoartrózy I. karpometakarpálního kloubu ruky
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2024)Date of defense: 18. 1. 2024Surgery Treatment in Advanced Osteoarthritis of the Thumb CMC Joint Abstract The thesis addresses therapy of advanced stages of degeneration of the first carpometacarpal joint. First carpometacarpal joint is crucial for ... -
Korelace genotypu a fenotypu vzácných onemocnění s využitím Human Phenotype Ontology k zefektivnění molekulárně genetické celogenomové diagnostiky
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2024)Date of defense: 1. 2. 2024Rare diseases are a diverse group of mostly inherited diseases with a very low prevalence of less than 1/2000 in the population. Identification of new genetic variants associated with these specific diseases is important ... -
Analýza pohybu bránice během její posturální funkce pomocí m-mode ultrasonografie v kombinaci se spirometrickým vyšetřením
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2024)Date of defense: 15. 2. 2024Analysis of diaphragm movement during its postural function using m-mode ultrasonography in conjunction with spirometry Abstract The diaphragm is a principal inspiratory muscle that, together with the abdominal wall muscles, ... -
Komplexní molekulární diagnostika gastrointestinálních stromálních nádorů
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2023)Date of defense: 21. 11. 2023Complex molecular diagnostics of gastrointestinal stromal tumors ABSTRACT Most of gastrointestinal stromal tumors (GISTs) are characterized by activating mutations in the KIT and PDGFRA genes (80 - 85 %). Mutations in the ... -
Selective regulation of presynaptic receptors by SGIP1
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2023)Date of defense: 20. 12. 2023Selective regulation of presynaptic receptors by SGIP1 Abstract Cannabinoid receptor 1 (CB1R) is involved in a plethora of physiological processes, such as memory formation, motor coordination, anxiety, pain perception, ... -
The role of SGIP1 protein in the control of cannabinoid receptor
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2023)Date of defense: 20. 12. 2023Two regions within the cannabinoid receptor 1 (CB1R) C-tail, 425 SMGDS429 and 460 TMSVSTDTS468 , contain clusters of serine and threonine residues that can be phosphorylated and collectively play an essential role in the ... -
Novel insights into the pathophysiology of growth retardation and other endocrine conditions: Lessons learned from consanguineous and non-consanguineous families
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2024)Date of defense: 15. 2. 2024 -
Molekulární mechanismus regulace funkce kaspasy-2 pomocí proteinů 14-3-3
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2024)Date of defense: 1. 2. 2024Molecular mechanism of 14-3-3 protein dependent regulation of caspase-2 Abstract Caspase-2 is a protease standing apically in the cascade of reactions leading to apoptosis. Properly functional apoptosis eliminates damaged ... -
Vliv hospitalizace dítěte na celou rodinu
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2024)Date of defense: 6. 6. 2024The bachelor thesis deals with the hospitalization of a child and all the factors that affect other family members in connection with the child's admission to a medical facility. The theoretical part of the thesis focuses ... -
Monitorace a tlumení bolesti u dětských pacientů po operaci defektu síňového septa se sternotomií
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2024)Date of defense: 6. 6. 2024Pain after cardiac surgery to correct developmental defects in pediatric patients is one of the most common nursing problems that affect overall recovery after surgery. This bachelor's thesis on "Monitoring and pain control ...