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Hodnocení a optimalizace granulačního procesu na laboratorním fluidním granulátoru.
dc.contributor.advisorMužíková, Jitka
dc.creatorStoniš, Jan
dc.date.accessioned2021-03-26T12:17:19Z
dc.date.available2021-03-26T12:17:19Z
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/20.500.11956/57976
dc.description.abstractThe fluid bed granulation is a well-established method how to improve such properties of powders as flowability and increase content uniformity of the tablets. In this thesis, there was evaluated a granulation process on a lab scale fluid Glatt bed granulator and optimized for highest possible yield. Product yield in the size range of 80-90 % of granules and process reproducibility were stated as most effective. The product was analysed for its particle size distribution, the API distribution within the different particle size fractions and the flowability of the final granules. For process optimization, the most critical parameters such as spraying rate, particle size of raw materials and fluid bed pressure were identified and evaluated. As the highest-yielding dosage for the powder binder was found the spraying rate of 9 g/min. Changes in bed fluid pressure and nozzle pressure showed no significant improvement. Different grades of caffeine were compared for their impact on the granulation properties. Sieved caffeine enhanced yield of the product and reproducibility compared to bulk or disagglomerated caffeine.en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, Farmaceutická fakulta v Hradci Královécs_CZ
dc.subjectgranulation processen_US
dc.subjectfluid bed granulatoren_US
dc.subjectspraing rateen_US
dc.subjectparticle sizeen_US
dc.subjectfluid bed pressureen_US
dc.subjectNIR measuringen_US
dc.titleEvaluation and optimisation of a granulation process on a laboratory scale fluid bed granulator.en_US
dc.typediplomová prácecs_CZ
dcterms.created2013
dcterms.dateAccepted2013-09-26
dc.description.departmentKatedra farmaceutické technologiecs_CZ
dc.description.departmentDepartment of Pharmaceutical Technologyen_US
dc.description.facultyFarmaceutická fakulta v Hradci Královécs_CZ
dc.description.facultyFaculty of Pharmacy in Hradec Královéen_US
dc.identifier.repId134385
dc.title.translatedHodnocení a optimalizace granulačního procesu na laboratorním fluidním granulátoru.cs_CZ
dc.contributor.refereeŘehula, Milan
dc.identifier.aleph001629465
thesis.degree.nameMgr.
thesis.degree.levelmagisterskécs_CZ
thesis.degree.disciplinePharmacyen_US
thesis.degree.disciplineFarmaciecs_CZ
thesis.degree.programFarmaciecs_CZ
thesis.degree.programPharmacyen_US
uk.thesis.typediplomová prácecs_CZ
uk.taxonomy.organization-csFarmaceutická fakulta v Hradci Králové::Katedra farmaceutické technologiecs_CZ
uk.taxonomy.organization-enFaculty of Pharmacy in Hradec Králové::Department of Pharmaceutical Technologyen_US
uk.faculty-name.csFarmaceutická fakulta v Hradci Královécs_CZ
uk.faculty-name.enFaculty of Pharmacy in Hradec Královéen_US
uk.faculty-abbr.csFaFcs_CZ
uk.degree-discipline.csFarmaciecs_CZ
uk.degree-discipline.enPharmacyen_US
uk.degree-program.csFarmaciecs_CZ
uk.degree-program.enPharmacyen_US
thesis.grade.csVýborněcs_CZ
thesis.grade.enExcellenten_US
uk.abstract.enThe fluid bed granulation is a well-established method how to improve such properties of powders as flowability and increase content uniformity of the tablets. In this thesis, there was evaluated a granulation process on a lab scale fluid Glatt bed granulator and optimized for highest possible yield. Product yield in the size range of 80-90 % of granules and process reproducibility were stated as most effective. The product was analysed for its particle size distribution, the API distribution within the different particle size fractions and the flowability of the final granules. For process optimization, the most critical parameters such as spraying rate, particle size of raw materials and fluid bed pressure were identified and evaluated. As the highest-yielding dosage for the powder binder was found the spraying rate of 9 g/min. Changes in bed fluid pressure and nozzle pressure showed no significant improvement. Different grades of caffeine were compared for their impact on the granulation properties. Sieved caffeine enhanced yield of the product and reproducibility compared to bulk or disagglomerated caffeine.en_US
uk.file-availabilityV
uk.grantorUniverzita Karlova, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologiecs_CZ
thesis.grade.code1
dc.contributor.consultantPolyak, Fabian
uk.publication-placeHradec Královécs_CZ
uk.thesis.defenceStatusO
dc.identifier.lisID990016294650106986


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