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Účinky oxidu uhličitého na neurovaskulární spojení během epileptické kortikální aktivity u potkanů
dc.contributor.advisorOtáhal, Jakub
dc.creatorJindrová, Martina
dc.date.accessioned2017-04-19T12:23:22Z
dc.date.available2017-04-19T12:23:22Z
dc.date.issued2010
dc.identifier.urihttp://hdl.handle.net/20.500.11956/21716
dc.description.abstractAim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused...cs_CZ
dc.description.abstractAim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused...en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, Fakulta tělesné výchovy a sportucs_CZ
dc.titleEffect of carbon dioxide on neurovascular coupling during cortical epileptic activity in rats.en_US
dc.typediplomová prácecs_CZ
dcterms.created2010
dcterms.dateAccepted2010-05-12
dc.description.departmentFyzioterapiecs_CZ
dc.description.facultyFaculty of Physical Education and Sporten_US
dc.description.facultyFakulta tělesné výchovy a sportucs_CZ
dc.identifier.repId85141
dc.title.translatedÚčinky oxidu uhličitého na neurovaskulární spojení během epileptické kortikální aktivity u potkanůcs_CZ
dc.contributor.refereeBrožíčková, Carole
dc.identifier.aleph001380357
thesis.degree.nameMgr.
thesis.degree.levelnavazující magisterskécs_CZ
thesis.degree.disciplineFyzioterapiecs_CZ
thesis.degree.disciplinePhysiotherapyen_US
thesis.degree.programSpecializace ve zdravotnictvícs_CZ
thesis.degree.programSpecializations in Health Serviceen_US
uk.thesis.typediplomová prácecs_CZ
uk.taxonomy.organization-csFakulta tělesné výchovy a sportu::Fyzioterapiecs_CZ
uk.faculty-name.csFakulta tělesné výchovy a sportucs_CZ
uk.faculty-name.enFaculty of Physical Education and Sporten_US
uk.faculty-abbr.csFTVScs_CZ
uk.degree-discipline.csFyzioterapiecs_CZ
uk.degree-discipline.enPhysiotherapyen_US
uk.degree-program.csSpecializace ve zdravotnictvícs_CZ
uk.degree-program.enSpecializations in Health Serviceen_US
thesis.grade.csVýborněcs_CZ
thesis.grade.enExcellenten_US
uk.abstract.csAim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused...cs_CZ
uk.abstract.enAim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused...en_US
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, Fakulta tělesné výchovy a sportu, Fyzioterapiecs_CZ


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