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Separácia enantiomérov liečiv a ich metabolitov chromatografickými metodami II
Enantiomeric separation of drugs and their metabolites II
Separace enantiomerů léčiv a jejich metabolitů chromatografickými metodami II
bachelor thesis (DEFENDED)
Advisor: Nobilis, Milan
Date Issued: 2019
Date of defense: 03. 06. 2019
Faculty / Institute: Farmaceutická fakulta v Hradci Králové / Faculty of Pharmacy in Hradec Králové
Abstract: Tramadol je centrálne pôsobiace opioidné analgetikum, ktoré je v pečeni pomocou enzýmu CYP2D6 premenené na účinnú látku O-demetyltramadol, zodpovednú za vznik opioidnej analgézie. V terapii je užívaný ako racemát. Chovanie ...
Tramadol is centrally acting opioid analgesic drug. It is converted in liver by the enzyme CYP2D6 into active substance O-desmethyltramadol, responsible for analgesia. In clinical practise it is used as racemate. Each ...
Tramadol is centrally acting opioid analgesic drug. It is converted in liver by the enzyme CYP2D6 into active substance O-desmethyltramadol, responsible for analgesia. In clinical practise it is used as racemate. Each ...