Genetický metabolismus. Vybrané genetické a hormonální faktory účastnící se jeho regulace
Energy metabolism control, selected genetic and hormonal factor
dissertation thesis (DEFENDED)
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http://hdl.handle.net/20.500.11956/95937Identifiers
Study Information System: 112358
Collections
- Kvalifikační práce [19614]
Author
Advisor
Referee
Rossmeisl, Martin
Pelikánová, Terezie
Faculty / Institute
Faculty of Science
Discipline
-
Department
Department of Anthropology and Human Genetics
Date of defense
26. 9. 2007
Publisher
Univerzita Karlova, Přírodovědecká fakultaLanguage
Czech
Grade
Pass
I I I I I I I 4, CONCLUSIONS r) The postulatedaim of thework was fulfilled: Quite a large cohorts of DM2 patients,direct offspring of DM2 patients,and obese subjectsas well as a group of women suffering from PCOS, and sufficiently large groupof controlsubjectswerecompleted a. All the probands underwenta detailed anthropometricand biochemical characeterization b. The DNA bank was establishedandcompleted An electronicdatabasewas established Molecular geneticmethodsPCR, RFLP, andSSCP wereestablishedandoptimized Specific polymorphismsin the selectedcandidategenes were genotypedand unique data regarding genotypic frequenciesof these polymorphisms in Czech population wereobtained Genetic, biochemical and anthropometric data underwent statistical analysis. Especially associationsbetweengeneticpolymorphisms/adipocytokineconcentrations andanthropometric/biochemicalparametersweretested Final resultswere evaluatedand possibleeffectof the studiedgeneticpolymorphisms and/oradipocytokineson body compositionanďor biochemical statuswas assessed. Also an eventual involvement of the studied genetic and hormonal factors in aethiopathogenesisof obesity,DMZ, metabolicsyndrome,and PCOS was considered Main resultsand conclusionsof theresearchwerepublishedin scientificjournals.The publicationsrepresentthepivotal partof...