Úloha proteinů tepelného šoku v patogenezi leukémie, reakce štěpu proti hostiteli, juvenilní idiopatické a revmatoidní artritidě
The role of heat shock proteins in pathogenesis of leukaemia, graft versus host disease, juvenile idiopathic and rheumatoid arthritis"
dizertační práce (OBHÁJENO)
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Trvalý odkaz
http://hdl.handle.net/20.500.11956/19889Identifikátory
SIS: 139141
Kolekce
- Kvalifikační práce [1715]
Autor
Vedoucí práce
Oponent práce
Říhová, Blanka
Prokešová, Ludmila
Fakulta / součást
2. lékařská fakulta
Obor
-
Katedra / ústav / klinika
Mimofakultní pracoviště
Datum obhajoby
11. 3. 2009
Nakladatel
Univerzita Karlova, 2. lékařská fakultaJazyk
Čeština
Známka
Prospěl/a
Úloha proteinů tepelného šoku v patogenezi leukémie, reakce štěpu proti hostiteli, juvenilní idiopatické a revmatoidní artritidě Powered by TCPDF (www.tcpdf.org)
The aims of the study: Heat shock proteins (Hsps) represent major immunodominant antigens in a wide spectrum of microbial pathogens and immune reactivity against different members of HSP families accompanies many infectious diseases. Known role of Hsps in antigen resentation could also suggest their potential role in the alloreactive process that leads to acute graft versus host disease (GvHD). sequence homology and cross-reactivity between microbial and human Hsps led to the concept that Hsps might be involved in the atiopathogenesis of autoimmune diseases such as juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA). The major groups of molecular chaperones have been implicated in cancer development as well and stress-inducible Hsp70 was found to be present on the plasma membrane of tumour cells but not on the corresponding normal tissues. On the basis of previous observations we focused our study on the role of Hsps, namely Hsp60 and Hsp70, in the pathogenesis of leukaemia, graft versus host disease, juvenil idiopathic arthritis and rheumatoid arthritis. Powered by TCPDF (www.tcpdf.org)