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Zobrazují se záznamy 21-40 z 19139
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Historické použití odpadu jáchymovské uranové továrny jako stavebního materiálu
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2023)Datum obhajoby: 31. 5. 2023Between 1853 and 1939, colourful and highly sought-after uranium paints were produced on an industrial scale in Jáchymov. Until the discovery of radium by Marie Curie Skłodowska in 1898, the waste from production was ... -
Překryvy regulonů stresových sigma faktorů RNA polymerázy korynebakterií a rhodokoků
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 7. 5. 2024Bacteria of the genera Rhodococcus and Corynebacterium are biotechnologically important microorganisms. This dissertation thesis focuses on the role of sigma (σ) factors of RNA polymerase in the regulation of gene expression ... -
Population dynamics of cushion plant Silene acaulis in the High Tatras
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 26. 5. 2021This diploma thesis is studying population dynamics of endangered species Silene acaulis in the High Tatra Mountains in Slovakia. Silene acaulis is a species of extreme alpine habitats creating cushions that provide a ... -
Population dynamics of Minuartia smejkalii
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 26. 5. 2021Serpentine areas in the Czech Republic form minor but important islands in the landscape with specific chemical properties such as high content of magnesium and other heavy metals. Due to this, serpentine is toxic for most ... -
Role AGO-hook domény histonového chaperonu SPT6L v regulaci genové exprese
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2022)Datum obhajoby: 27. 5. 2022AGO-hook domains present in some eucaryotic proteins are crucial for a binding family of ARGONAUTE proteins (AGO). These AGO proteins are essential in many biological processes regulating gene expression by small RNA (sRNA), ... -
Interakce proteinů Whi3 a Yap6 při mírném osmotickém stresu
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 26. 5. 2021Natural strains of the Saccharomyces cerevisiae growing on solid médium form structured, biofilm -like colonies. This ability is depended on the surface adhesin Flo11p. The expression of the FLO11 gene is upregulated by ... -
Úloha chloroplastů ve středním válci kořenů epifytických orchidejí
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 26. 5. 2021The photosynthesis of the aerial roots of epiphytic orchids has been the subject of numerous studies. However, the roots are always evaluated as a homogeneous structure, even though they actually consist of significantly ... -
Studium prekurzorových forem SARS-CoV-2 3-CL proteázy
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2023)Datum obhajoby: 30. 5. 2023The SARS-CoV-2 virus (Severe acute respiratory syndrome coronavirus 2), the causative agent of the disease COVID-19 (coronavirus disease 2019), is an enveloped virus with a positive RNA genome. After the binding of the ... -
Vliv chladové adaptace na aktivaci adrenergních a tyroidních signálních drah v myokardu potkana.
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 20. 5. 2021Despite advances in research and therapy, cardiovascular diseases are still the leading cause of death worldwide. A closer understanding of the endogenous protective mechanism may improve pharmacological interventions for ... -
Macromolecular avenues for the creation of bio-inspired hierarchically structured surfaces
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 26. 4. 2024Biomedical applications often rely on surface adherent architectures such as polymer brushes to prevent adverse nonspecific interactions between materials used in biomedicine and contacting biological fluids. Commonly, ... -
Magnetic nanoparticles with antibacterial properties: Synthesis, characterization and biological applications
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 26. 4. 2024In response to the escalating global threat of antibiotic resistance, innovative strategies are imperative. This thesis focuses on surface-engineered magnetic nanoparticles (MNPs) with potent antibacterial properties, ... -
KT/HAK/KUP High-affinity Transporters in Plants
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 26. 4. 2024Due to its essential role in plant metabolism and often low availability in the soil, sufficient potassium uptake and management are among the challenges plants face to survive in different environments. Since all potassium ... -
Modeling of biologically relevant lipid multilayers in the context of drug delivery
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 25. 4. 2024Understanding the topical drug delivery at basic physico-chemical and biophysical levels is still challenging. One of the main reasons is the specificity of the processes involved, depending on the delivery target. The ... -
Palaeoecological aspects and evolution of the Late Cretaceous oyster assemblages
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 25. 4. 2024The presented thesis explores the palaeoecological aspects of the evolution of the well-known fossil oyster genus Rhynchostreon Bayle, 1874, a significant representative of Cretaceous fauna. The study integrates sedimentological ... -
Vývoj hmotnostně-spektrometrických metod pro strukturní analýzu mastných kyselin a estolidů
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 23. 4. 2024(EN) This doctoral thesis summarizes the use of modern mass spectrometric methods for the structural identification of fatty acids and triacylglycerol estolides (TG-EST) and their subsequent characterization in the lipidome ... -
Development and utilization of electrochemical flow-through detectors
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 23. 4. 2024The proposed dissertation thesis deals with the development and investigation of electrochemical flow systems using both conventional and unconventional electrode materials. In the first part of this thesis, the problem ... -
Atomic fluorescence spectrometry with volatile species generation - a sensitive tool for ultra-trace elemental analysis
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 9. 5. 2024This thesis encompasses a development of innovative methodologies based on atomic fluorescence spectrometry, offering precise and sensitive determination of ultra-trace elements, such as bismuth, cadmium, and nickel. The ... -
Host Specialization and Evolution of Cuckoo Behavior in Bees
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 22. 4. 2024Cuckoo bees are nest parasites of solitary and sometimes also social bee species. They do not build their own nests. Nor do they provision their larvae. Instead, they seek out a suitable host nest to lay their eggs in, and ... -
Study of the substrate specificity of the LACTB tumour suppressor enzyme
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2019)Datum obhajoby: 19. 9. 2019Serine beta-lactamase-like protein (LACTB) is a tumour suppressor that modulates mitochondrial lipid metabolism and induces differentiation of breast cancer cells. This is achieved by the LACTB-dependent downregulation of ... -
Ecology of bryophytes in post mining sites
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2023)Datum obhajoby: 22. 5. 2023Mining sites offer a mosaic of spoil heaps of different age, with diverse substrate characteristics. Especially problematic for vegetation development can be toxic spoil heaps with substrate from the Tertiary rocks ...
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