The disease diabetes mellitus is reaching an alarming level worldwide and its prevalence is rising sharply every year. The Czech Republic has over a million patients with this disease. This is a major societal problem, ...

Over the past decade, scientific research has focused on the intricate relationship between the human microbiome and the immune system. A particular emphasis in the last three years has been on investigating the impact of ...

This bachelor's thesis discusses the issue of gestational diabetes and the influence of the diagnosis on nutrition and exercise/sport in diagnosed women. The theoretical part discusses the pathogenesis of GDM, risk factors ...

Palliative care is an approach focused on improving or maintaining quality of life for patients and their families who suffer from terminal illness in an advanced stage. Hospices are most commonly associated with palliative ...

The topic of this bachelor thesis is the issue of nutritionally important components of fish muscle in the prevention of serious diseases. Fish meat is a rich source of essential amino acids, polyunsaturated fatty acids, ...

The obesity epidemic is still a very topical problem and requires a comprehensive therapy that includes nutritional counselling. In my practical experience, the topic of protein and fibre tends to be very common with obese ...

EN The objective of this work was to study novel synthetic iron chelators and to study their potential use in inhibition of TET1 (ten-eleven translocation methylcytosine dioxygenase 1) protein. Epigenetic mechanisms, such ...

In my dissertation, I studied the genetic predisposition of selected types of cancer that have not been systematically studied in the Czech Republic. We used next-generation panel sequencing to identify germline pathogenic ...

Thin fibrous cap atheroma with a high lipid content is the most common morphological substrate for acute coronary syndrome. Lipid content can be reliably determined by near infrared spectroscopy (NIRS) imaging. Optical ...

Steroid hormones can be divided into 2 groups - intracellular and extracellular, depending on location of their activity. Intracellular ones influence expression of genes while acting as transcription factors. This so-called ...

Background: In Czech Republic, the use of addictive substances in the general population is regularly evaluated. In people with spinal cord lesions, the issue of substance abuse is not sufficiently mapped. Difficulty to ...

BACHELOR THESIS ABSTRAKT Name, Surname: Jana Račanová Supervisor: Bc. Zuzana Rodová M.Sc. Title: Instruments for evaluation of the structure of the day in the occupational therapy Abstract: The bachelor thesis is ...

The dissertation evaluates the results of a first metatarsophalangeal (MTP) joint replacement. The PH-Flex MTP joint replacement was developed at the 1st Department of Orthopaedics, the first faculty of medicine in conjunction ...

Background: Understanding patterns of use and the needs of young adult users of illegal addictive substances presents a challenge primarily due to the hidden nature of this problem. Individuals engaging in problem drug use ...

Background: Human needs encompass a spectrum ranging from fundamental physiological requirements, such as breathing and sustenance, to elevated needs like love and appreciation. While most individuals fulfill these needs ...

Background: Music is an essential part of human life. Substance use is often associated with music artists, but research has shown that the risk extends to their listeners. Studies show that the genres at risk include rock, ...

Purines are involved in many biologic processes and are required to maintain stable energy charge, for metabolic regulation, as cofactors in enzymatic reactions and as building blocks in DNA and RNA. Necessary role in ...

During intrauterine development in mammals, the fetus is exposed to a hypoxic environment. To allow proper postnatal adaptation to external conditions, a rapid transition from glycolytic to oxidative metabolism by mitochondria ...

Inherited disorders of glycosylation (CDG) are a large group of more than 160 types of metabolic disorders caused by genetic defects that lead to impaired glycan biosynthesis and modification. The lipid dolichol plays an ...

Background: Mitragyna Speciosa - a plant, more commonly known as kratom, that has a history and tradition in Southeast Asia for centuries. In recent decades, it has been gaining popularity worldwide. In addition to its ...