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Rich Information Optical Biosensor Based on Surface Plasmon Resonance
dc.contributor.advisorHomola, Jiří
dc.creatorDostálek, Jakub
dc.date.accessioned2021-01-15T17:44:03Z
dc.date.available2021-01-15T17:44:03Z
dc.date.issued2006
dc.identifier.urihttp://hdl.handle.net/20.500.11956/7491
dc.description.abstractIn the presented thesis, new optical biosensor platform for high-throughput label-free monitoring of biomolecular interactions is reported. This biosensor platform is based on a spectroscopy of surface plasmons on an array of miniature diffraction gratings. Each miniature grating serves as an independent sensing channel and allows for monitoring of optical density changes induced by biomolecular interactions on the grating surface. The presented platform has a potential for monitoring of hundreds of interactions on a single sensor chip. The presented research include theoretical study of surface plasmon resonance on metallic diffraction gratings and the analysis of diffraction grating-based SPR biosensor. In the experimental work, preparation, replication and characterization of diffraction gratings is carried out. A prototype SPR sensor device including an SPR sensor chip with a twodimensional array of sensing channels, fluidic system and SPR chip reader is developed and its main performance characteristics are determined.en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, Matematicko-fyzikální fakultacs_CZ
dc.titleRich Information Optical Biosensor Based on Surface Plasmon Resonanceen_US
dc.typedizertační prácecs_CZ
dcterms.created2006
dcterms.dateAccepted2006-09-26
dc.description.facultyMatematicko-fyzikální fakultacs_CZ
dc.description.facultyFaculty of Mathematics and Physicsen_US
dc.identifier.repId40341
dc.title.translatedRich Information Optical Biosensor Based on Surface Plasmon Resonancecs_CZ
dc.contributor.refereeRichter, Ivan
dc.contributor.refereeVrbová, Miroslava
dc.identifier.aleph000857313
thesis.degree.namePh.D.
thesis.degree.leveldoktorskécs_CZ
thesis.degree.disciplineQuantum Optics and Optoelectronicsen_US
thesis.degree.disciplineKvantová optika a optoelektronikacs_CZ
thesis.degree.programPhysicsen_US
thesis.degree.programFyzikacs_CZ
uk.thesis.typedizertační prácecs_CZ
uk.faculty-name.csMatematicko-fyzikální fakultacs_CZ
uk.faculty-name.enFaculty of Mathematics and Physicsen_US
uk.faculty-abbr.csMFFcs_CZ
uk.degree-discipline.csKvantová optika a optoelektronikacs_CZ
uk.degree-discipline.enQuantum Optics and Optoelectronicsen_US
uk.degree-program.csFyzikacs_CZ
uk.degree-program.enPhysicsen_US
thesis.grade.csProspěl/acs_CZ
thesis.grade.enPassen_US
uk.abstract.enIn the presented thesis, new optical biosensor platform for high-throughput label-free monitoring of biomolecular interactions is reported. This biosensor platform is based on a spectroscopy of surface plasmons on an array of miniature diffraction gratings. Each miniature grating serves as an independent sensing channel and allows for monitoring of optical density changes induced by biomolecular interactions on the grating surface. The presented platform has a potential for monitoring of hundreds of interactions on a single sensor chip. The presented research include theoretical study of surface plasmon resonance on metallic diffraction gratings and the analysis of diffraction grating-based SPR biosensor. In the experimental work, preparation, replication and characterization of diffraction gratings is carried out. A prototype SPR sensor device including an SPR sensor chip with a twodimensional array of sensing channels, fluidic system and SPR chip reader is developed and its main performance characteristics are determined.en_US
uk.file-availabilityV
uk.grantorUniverzita Karlova, Matematicko-fyzikální fakultacs_CZ
thesis.grade.codeP
uk.publication-placePrahacs_CZ
uk.thesis.defenceStatusO
uk.departmentExternal.nameÚstav fotoniky a elektroniky AV ČR, v.v.i.cs
dc.identifier.lisID990008573130106986


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