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Separation and determination of pharmaceutically important compounds using electrophoretic methods
dc.contributor.advisorPospíšilová, Marie
dc.creatorHamoudová, Rafífa
dc.date.accessioned2018-10-19T10:05:19Z
dc.date.available2018-10-19T10:05:19Z
dc.date.issued2006
dc.identifier.urihttp://hdl.handle.net/20.500.11956/7456
dc.description.abstractThis thesis deals with the use of electrophoretic methods in the analysis of pharmaceutically important compounds. In the theoretical part, the classification of capillary electrophoretic techniques is discussed. Capillary zone electrophoresis (CZE, capillary isotachophoresis (ITP), micellar elektrokinetic chromatography (MEKC), microemulsion elektrokinetic chromatography (MEEKC), isoelectric focusation (IEF), capillary electrochromatography (CEC) and capillary gel electrophoresis (CGE) are described. Further, on-line pre-concentration methods are described. Particular attention is given to the on-line combination of capillary isotachophoresis with capillary zone electrophoresis using column coupling arrangement. This combination enables the improvement of the selectivity of separation and the improvement of the limit of detection of analytes present in complex matrices of biological and environmental origin. Afterwards, the results of the experimental analyses are presented: 1. The first paper deals with the use of CZE in the analysis of ibuprofen and flurbiprofen in pharmaceuticals. Separation was carried out in a fused silica capillary (60 cm x 100 m I.D effective length 45 cm) at 30 kV with UV detection at 232 nm. The optimized background electrolyte was 20mM N-(2- acetamido)-2-aminoethanesulfonic acid...en_US
dc.languageČeštinacs_CZ
dc.language.isocs_CZ
dc.publisherUniverzita Karlova, Farmaceutická fakulta v Hradci Královécs_CZ
dc.titleSeparace a stanovení farmaceuticky významných látek s využitím elektroforetických metodcs_CZ
dc.typedizertační prácecs_CZ
dcterms.created2006
dcterms.dateAccepted2006-09-26
dc.description.departmentKatedra analytické chemiecs_CZ
dc.description.departmentDepartment of Analytical Chemistryen_US
dc.description.facultyFaculty of Pharmacy in Hradec Královéen_US
dc.description.facultyFarmaceutická fakulta v Hradci Královécs_CZ
dc.identifier.repId17904
dc.title.translatedSeparation and determination of pharmaceutically important compounds using electrophoretic methodsen_US
dc.contributor.refereeNobilis, Milan
dc.contributor.refereeJokl, Vladimír
dc.identifier.aleph000583627
thesis.degree.namePh.D.
thesis.degree.leveldoktorskécs_CZ
thesis.degree.disciplineDrug Controlen_US
thesis.degree.disciplineKontrola chemických léčivcs_CZ
thesis.degree.programPharmacyen_US
thesis.degree.programFarmaciecs_CZ
uk.thesis.typedizertační prácecs_CZ
uk.taxonomy.organization-csFarmaceutická fakulta v Hradci Králové::Katedra analytické chemiecs_CZ
uk.taxonomy.organization-enFaculty of Pharmacy in Hradec Králové::Department of Analytical Chemistryen_US
uk.faculty-name.csFarmaceutická fakulta v Hradci Královécs_CZ
uk.faculty-name.enFaculty of Pharmacy in Hradec Královéen_US
uk.faculty-abbr.csFaFcs_CZ
uk.degree-discipline.csKontrola chemických léčivcs_CZ
uk.degree-discipline.enDrug Controlen_US
uk.degree-program.csFarmaciecs_CZ
uk.degree-program.enPharmacyen_US
thesis.grade.csProspěl/acs_CZ
thesis.grade.enPassen_US
uk.abstract.enThis thesis deals with the use of electrophoretic methods in the analysis of pharmaceutically important compounds. In the theoretical part, the classification of capillary electrophoretic techniques is discussed. Capillary zone electrophoresis (CZE, capillary isotachophoresis (ITP), micellar elektrokinetic chromatography (MEKC), microemulsion elektrokinetic chromatography (MEEKC), isoelectric focusation (IEF), capillary electrochromatography (CEC) and capillary gel electrophoresis (CGE) are described. Further, on-line pre-concentration methods are described. Particular attention is given to the on-line combination of capillary isotachophoresis with capillary zone electrophoresis using column coupling arrangement. This combination enables the improvement of the selectivity of separation and the improvement of the limit of detection of analytes present in complex matrices of biological and environmental origin. Afterwards, the results of the experimental analyses are presented: 1. The first paper deals with the use of CZE in the analysis of ibuprofen and flurbiprofen in pharmaceuticals. Separation was carried out in a fused silica capillary (60 cm x 100 m I.D effective length 45 cm) at 30 kV with UV detection at 232 nm. The optimized background electrolyte was 20mM N-(2- acetamido)-2-aminoethanesulfonic acid...en_US
uk.file-availabilityV
uk.publication.placeHradec Královécs_CZ
uk.grantorUniverzita Karlova, Farmaceutická fakulta v Hradci Králové, Katedra analytické chemiecs_CZ
thesis.grade.codeP
dc.identifier.lisID990005836270106986


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