dc.contributor.advisor | Roeselová, Martina | |
dc.creator | Kukharchuk, Alexandra | |
dc.date.accessioned | 2021-03-24T21:59:37Z | |
dc.date.available | 2021-03-24T21:59:37Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11956/63977 | |
dc.description.abstract | Tato práce se zabývá studiem interakcí mezi aminokyselinami s hydrofobním postranním řetězcem a fosfolipidovou monovrstvou na rozhraní voda-vzduch pomocí molekulové dynamiky. Byly provedeny tři simulace: a) simulace leucinu ve vodném roztoku, b) simulace povrchu vodného roztoku leucinu c) simulace roztoku leucinu s monovrstvou fosfolipidů DPPC na povrchu. Tyto simulace ukázaly, že leucin jeví povrchovou aktivitu a má tendenci tvořit klastry, a to přednostně na vodném povrchu. Rovněž bylo zjištěno, že leucin interkaluje mezi molekuly DPPC, což vede ke vzniku drobných pórů v DPPC monovrstvě. Výsledky simulace leucinu s DPPC monovrstvou byly porovnány s výsledky již dříve provedené obdobné simulace pro fenylalanin. Toto porovnání ukázalo, že molekuly fenylalaninu pronikají do DPPC monovrstvy více než molekuly leucinu, ačkoliv hloubka zanoření mezi molekuly DPPC je u obou aminokyselin prakticky stejná. Powered by TCPDF (www.tcpdf.org) | cs_CZ |
dc.description.abstract | The aim of the thesis is to get insight into the interactions between amino acids with a hydrophobic side- chain and a phospholipid monolayer on the water-air interface via molecular dynamics. There were three simulations performed: a) simulation of leucine in aqueous solution, b) simulation of leucine at the solution - air interface c) simulation of leucine solution with DPPC phospholipid monolayer at its surface. These simulations demonstrate that leucine shows surface activity and tendency to aggregate, particularly at the water surface. This tendency also remains in the presence of DPPC monolayer. In addition, intercalation of leucine between DPPC molecules was observed, leading to creation of small pores in the DPPC monolayer. The results of the simulation with leucine were compared with the results of a previously done analogous simulation with phenylalanine. The comparison showed that phenylalanine penetrates into the DPPC monolayer more than leucine, however the depth of penetration between DPPC molecules is almost the same for both amino acids. Powered by TCPDF (www.tcpdf.org) | en_US |
dc.language | Čeština | cs_CZ |
dc.language.iso | cs_CZ | |
dc.publisher | Univerzita Karlova, Matematicko-fyzikální fakulta | cs_CZ |
dc.subject | Langmuir monolayers | en_US |
dc.subject | pulmonary surfactant | en_US |
dc.subject | specific intermolecular interactions | en_US |
dc.subject | intercalation | en_US |
dc.subject | Langmuirovy monovrstvy | cs_CZ |
dc.subject | plicní surfaktant | cs_CZ |
dc.subject | specifické mezimolekulové interakce | cs_CZ |
dc.subject | interkalace | cs_CZ |
dc.title | Interakce aminokyselin s fosfolipidovými monovrstvami | cs_CZ |
dc.type | bakalářská práce | cs_CZ |
dcterms.created | 2014 | |
dcterms.dateAccepted | 2014-09-11 | |
dc.description.department | Department of Chemical Physics and Optics | en_US |
dc.description.department | Katedra chemické fyziky a optiky | cs_CZ |
dc.description.faculty | Faculty of Mathematics and Physics | en_US |
dc.description.faculty | Matematicko-fyzikální fakulta | cs_CZ |
dc.identifier.repId | 143298 | |
dc.title.translated | Interaction of aminoacids with phospholipid monolayers | en_US |
dc.contributor.referee | Pospíšil, Miroslav | |
dc.identifier.aleph | 001852614 | |
thesis.degree.name | Bc. | |
thesis.degree.level | bakalářské | cs_CZ |
thesis.degree.discipline | Obecná fyzika | cs_CZ |
thesis.degree.discipline | General Physics | en_US |
thesis.degree.program | Physics | en_US |
thesis.degree.program | Fyzika | cs_CZ |
uk.thesis.type | bakalářská práce | cs_CZ |
uk.taxonomy.organization-cs | Matematicko-fyzikální fakulta::Katedra chemické fyziky a optiky | cs_CZ |
uk.taxonomy.organization-en | Faculty of Mathematics and Physics::Department of Chemical Physics and Optics | en_US |
uk.faculty-name.cs | Matematicko-fyzikální fakulta | cs_CZ |
uk.faculty-name.en | Faculty of Mathematics and Physics | en_US |
uk.faculty-abbr.cs | MFF | cs_CZ |
uk.degree-discipline.cs | Obecná fyzika | cs_CZ |
uk.degree-discipline.en | General Physics | en_US |
uk.degree-program.cs | Fyzika | cs_CZ |
uk.degree-program.en | Physics | en_US |
thesis.grade.cs | Velmi dobře | cs_CZ |
thesis.grade.en | Very good | en_US |
uk.abstract.cs | Tato práce se zabývá studiem interakcí mezi aminokyselinami s hydrofobním postranním řetězcem a fosfolipidovou monovrstvou na rozhraní voda-vzduch pomocí molekulové dynamiky. Byly provedeny tři simulace: a) simulace leucinu ve vodném roztoku, b) simulace povrchu vodného roztoku leucinu c) simulace roztoku leucinu s monovrstvou fosfolipidů DPPC na povrchu. Tyto simulace ukázaly, že leucin jeví povrchovou aktivitu a má tendenci tvořit klastry, a to přednostně na vodném povrchu. Rovněž bylo zjištěno, že leucin interkaluje mezi molekuly DPPC, což vede ke vzniku drobných pórů v DPPC monovrstvě. Výsledky simulace leucinu s DPPC monovrstvou byly porovnány s výsledky již dříve provedené obdobné simulace pro fenylalanin. Toto porovnání ukázalo, že molekuly fenylalaninu pronikají do DPPC monovrstvy více než molekuly leucinu, ačkoliv hloubka zanoření mezi molekuly DPPC je u obou aminokyselin prakticky stejná. Powered by TCPDF (www.tcpdf.org) | cs_CZ |
uk.abstract.en | The aim of the thesis is to get insight into the interactions between amino acids with a hydrophobic side- chain and a phospholipid monolayer on the water-air interface via molecular dynamics. There were three simulations performed: a) simulation of leucine in aqueous solution, b) simulation of leucine at the solution - air interface c) simulation of leucine solution with DPPC phospholipid monolayer at its surface. These simulations demonstrate that leucine shows surface activity and tendency to aggregate, particularly at the water surface. This tendency also remains in the presence of DPPC monolayer. In addition, intercalation of leucine between DPPC molecules was observed, leading to creation of small pores in the DPPC monolayer. The results of the simulation with leucine were compared with the results of a previously done analogous simulation with phenylalanine. The comparison showed that phenylalanine penetrates into the DPPC monolayer more than leucine, however the depth of penetration between DPPC molecules is almost the same for both amino acids. Powered by TCPDF (www.tcpdf.org) | en_US |
uk.file-availability | V | |
uk.grantor | Univerzita Karlova, Matematicko-fyzikální fakulta, Katedra chemické fyziky a optiky | cs_CZ |
thesis.grade.code | 2 | |
dc.contributor.consultant | Jungwirth, Pavel | |
uk.publication-place | Praha | cs_CZ |
uk.thesis.defenceStatus | O | |
dc.identifier.lisID | 990018526140106986 | |