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Imunoprotektivní vlastnosti polymerních cytostatik
dc.contributor.advisorŘíhová, Blanka
dc.creatorŠírová, Milada
dc.date.accessioned2019-05-03T18:48:01Z
dc.date.available2019-05-03T18:48:01Z
dc.date.issued2010
dc.identifier.urihttp://hdl.handle.net/20.500.11956/34928
dc.description.abstract18 I. INTRODUCTION Cancer is a serious health problem worldwide. In economically developed countries, it is a second most frequent cause of death after cardiovascular dis- eases, and the number of oncological patients continuously increases with the increasing age of population. The mainstay of cancer therapy is combination of surgery, radiation and chemotherapy. Whilst surgery and radiation are relatively precise and suitable to achieve a local control over the tumor, chemotherapy exerts a systemic ef- fect. These three modalities, when properly combined and sequenced, can cure a substantial number of hematological cancers and a smaller, but still significant subset of various solid tumors. Most cytostatic/cytotoxic drugs that are now in common use target the cells with high proliferation rate. The non-selective character of chemotherapy leads to increased toxicities towards normal rapidly proliferating cells. This means that the drugs have to be used at suboptimal doses, leading to development of (multi)drug resistance, metastatic disease and, eventually, to failure of the therapy. Innovative therapeutic strategies need to be developed in order to achieve better treatment outcome. For that purpose, several approaches are be- ing applied. First, sophisticated genomic and proteomic research could identify...en_US
dc.description.abstractDizertační práce RNDr. Milada Šírová Školitelka: prof. RNDr. Blanka Říhová, DrSc. Sektor imunologie a gnotobiologie Mikrobiologický ústav Akademie věd České republiky Praha, květen 2010 CHARLES UNIVERSITY IN PRAGUE Faculty of Natural Sciences PhD. Thesis in Immunology Cytostatic and Immunomodulatory Properties of Polymeric Prodrugs RNDr. Tomáš Mrkvan Supervisor: Prof. RNDr. Blanka �íhová, DrSc. Department of Immunology and Gnotobiology Institute of Microbiology Academy of Sciences of the Czech Republic Prague, March 2006 UNIVERZITA KARLOVA V PRAZE PŘÍRODOVĚDECKÁ FAKULTA IMUNOPROTEKTIVNÍ VLASTNOSTI POLYMERNÍCH CYTOSTATIK IMMUNOPROTECTIVE CHARACTER OF POLYMER CYTOTOXIC DRUGS 2 DOKTORSKÉ STUDIJNÍ PROGRAMY V BIOMEDICÍNĚ UNIVERZITA KARLOVA V PRAZE A AKADEMIE VĚD ČESKÉ REPUBLIKY PROGRAM: IMUNOLOGIE PŘEDSEDA OBOROVÉ RADY: DOC. RNDR. VLADIMÍR HOLÁŇ, DRSC. ŠKOLICÍ PRACOVIŠTĚ: MIKROBIOLOGICKÝ ÚSTAV AVČR, V. V. I. AUTOR: MILADA ŠÍROVÁ ŠKOLITEL: PROF. RNDR. BLANKA ŘÍHOVÁ, DRSC. ŠKOLITEL KONSULTANT (BYL-LI): NE S DISERTACÍ JE MOŽNO SE SEZNÁMIT NA DĚKANÁTĚ PŘÍRODOVĚDECKÉ FAKULTY UNIVERZITY KARLOVY V PRAZE 1 OBSAH I. ÚVOD .................................................................................................... 3 I.1. Cílená léčba nádorových onemocnění................................................... 3 I.2....cs_CZ
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, Přírodovědecká fakultacs_CZ
dc.titleImmunoprotective character of polymer cytotoxic drugsen_US
dc.typedizertační prácecs_CZ
dcterms.created2010
dcterms.dateAccepted2010-09-13
dc.description.departmentDepartment of Cell Biologyen_US
dc.description.departmentKatedra buněčné biologiecs_CZ
dc.description.facultyFaculty of Scienceen_US
dc.description.facultyPřírodovědecká fakultacs_CZ
dc.identifier.repId84470
dc.title.translatedImunoprotektivní vlastnosti polymerních cytostatikcs_CZ
dc.contributor.refereeTuránek, Jaroslav
dc.contributor.refereeRabišková, Miloslava
dc.identifier.aleph001299030
thesis.degree.namePh.D.
thesis.degree.leveldoktorskécs_CZ
thesis.degree.disciplineImunologiecs_CZ
thesis.degree.disciplineImmunologyen_US
thesis.degree.programFyziologie a imunologiecs_CZ
thesis.degree.programPhysiology and Immunologyen_US
uk.faculty-name.csPřírodovědecká fakultacs_CZ
uk.faculty-name.enFaculty of Scienceen_US
uk.faculty-abbr.csPřFcs_CZ
uk.degree-discipline.csImunologiecs_CZ
uk.degree-discipline.enImmunologyen_US
uk.degree-program.csFyziologie a imunologiecs_CZ
uk.degree-program.enPhysiology and Immunologyen_US
thesis.grade.csProspěl/acs_CZ
thesis.grade.enPassen_US
uk.abstract.csDizertační práce RNDr. Milada Šírová Školitelka: prof. RNDr. Blanka Říhová, DrSc. Sektor imunologie a gnotobiologie Mikrobiologický ústav Akademie věd České republiky Praha, květen 2010 CHARLES UNIVERSITY IN PRAGUE Faculty of Natural Sciences PhD. Thesis in Immunology Cytostatic and Immunomodulatory Properties of Polymeric Prodrugs RNDr. Tomáš Mrkvan Supervisor: Prof. RNDr. Blanka �íhová, DrSc. Department of Immunology and Gnotobiology Institute of Microbiology Academy of Sciences of the Czech Republic Prague, March 2006 UNIVERZITA KARLOVA V PRAZE PŘÍRODOVĚDECKÁ FAKULTA IMUNOPROTEKTIVNÍ VLASTNOSTI POLYMERNÍCH CYTOSTATIK IMMUNOPROTECTIVE CHARACTER OF POLYMER CYTOTOXIC DRUGS 2 DOKTORSKÉ STUDIJNÍ PROGRAMY V BIOMEDICÍNĚ UNIVERZITA KARLOVA V PRAZE A AKADEMIE VĚD ČESKÉ REPUBLIKY PROGRAM: IMUNOLOGIE PŘEDSEDA OBOROVÉ RADY: DOC. RNDR. VLADIMÍR HOLÁŇ, DRSC. ŠKOLICÍ PRACOVIŠTĚ: MIKROBIOLOGICKÝ ÚSTAV AVČR, V. V. I. AUTOR: MILADA ŠÍROVÁ ŠKOLITEL: PROF. RNDR. BLANKA ŘÍHOVÁ, DRSC. ŠKOLITEL KONSULTANT (BYL-LI): NE S DISERTACÍ JE MOŽNO SE SEZNÁMIT NA DĚKANÁTĚ PŘÍRODOVĚDECKÉ FAKULTY UNIVERZITY KARLOVY V PRAZE 1 OBSAH I. ÚVOD .................................................................................................... 3 I.1. Cílená léčba nádorových onemocnění................................................... 3 I.2....cs_CZ
uk.abstract.en18 I. INTRODUCTION Cancer is a serious health problem worldwide. In economically developed countries, it is a second most frequent cause of death after cardiovascular dis- eases, and the number of oncological patients continuously increases with the increasing age of population. The mainstay of cancer therapy is combination of surgery, radiation and chemotherapy. Whilst surgery and radiation are relatively precise and suitable to achieve a local control over the tumor, chemotherapy exerts a systemic ef- fect. These three modalities, when properly combined and sequenced, can cure a substantial number of hematological cancers and a smaller, but still significant subset of various solid tumors. Most cytostatic/cytotoxic drugs that are now in common use target the cells with high proliferation rate. The non-selective character of chemotherapy leads to increased toxicities towards normal rapidly proliferating cells. This means that the drugs have to be used at suboptimal doses, leading to development of (multi)drug resistance, metastatic disease and, eventually, to failure of the therapy. Innovative therapeutic strategies need to be developed in order to achieve better treatment outcome. For that purpose, several approaches are be- ing applied. First, sophisticated genomic and proteomic research could identify...en_US
uk.file-availabilityN
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, Přírodovědecká fakulta, Katedra buněčné biologiecs_CZ
thesis.grade.codeP


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