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Proteiny tepelného šoku: terapeutický přístup v onkologii
dc.contributor.advisorHromadníková, Ilona
dc.creatorRutkowski, Radoslaw
dc.date.accessioned2018-09-12T10:49:11Z
dc.date.available2018-09-12T10:49:11Z
dc.date.issued2010
dc.identifier.urihttp://hdl.handle.net/20.500.11956/29763
dc.description.abstractSince the discovery of heat shock proteins in 1960s and their immunogenic properties 20 years later in 1980s they have been under rigorous investigation with great hopes for advent of immunotherapy in oncology as well as other pathologies. So are the HSPs a breakthrough in therapy of cancers or will they be just another form of palliative treatment of these notorious and deadly diseases? HSPs is a family of proteins expressed virtually by all living organisms. These proteins have a number of functions that are crucial to organism's intracellular and extracellular homeostasis. Due to the significance of HSPs, over the eons of the evolution, they have been highly conserved in our genetic code. The human HSPs shares almost 50 percent homology with simple unicellular prokaryotes to well over 95 percent homology with higher species of living organisms. Despite of the fact that HSPs have been knows for approximately 50 years and despite of the intensive resears in the field, currently Russia is the only place where HSP immunotherapy has been approved as of 2008 for treatment in renal cell carcinoma. The HSPs immunotherapy has proven benefitial as an adjuvant treatment in some stages of a selected cancers. The advantage of HPSs immunotherapy is that it has less side effects compared to standart chemotherapy...en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, 3. lékařská fakultacs_CZ
dc.titleHeat Shock Proteins - Focus on Therapeutic Approaches in Oncologyen_US
dc.typediplomová prácecs_CZ
dcterms.created2010
dcterms.dateAccepted2010-04-07
dc.description.departmentGynekologicko porodnická klinika - oddělení molekulární biologie a patologie buňkycs_CZ
dc.description.departmentDepartment of Gynaecology and Obstetrics - Division of Molecular Biology and Cell Pathologyen_US
dc.description.facultyThird Faculty of Medicineen_US
dc.description.faculty3. lékařská fakultacs_CZ
dc.identifier.repId65841
dc.title.translatedProteiny tepelného šoku: terapeutický přístup v onkologiics_CZ
dc.identifier.aleph001224001
thesis.degree.nameMUDr.
thesis.degree.levelmagisterskécs_CZ
thesis.degree.discipline-cs_CZ
thesis.degree.discipline-en_US
thesis.degree.programGeneral Medicineen_US
thesis.degree.programVšeobecné lékařstvícs_CZ
uk.faculty-name.cs3. lékařská fakultacs_CZ
uk.faculty-name.enThird Faculty of Medicineen_US
uk.faculty-abbr.cs3.LFcs_CZ
uk.degree-discipline.cs-cs_CZ
uk.degree-discipline.en-en_US
uk.degree-program.csVšeobecné lékařstvícs_CZ
uk.degree-program.enGeneral Medicineen_US
thesis.grade.csVýborněcs_CZ
thesis.grade.enExcellenten_US
uk.abstract.enSince the discovery of heat shock proteins in 1960s and their immunogenic properties 20 years later in 1980s they have been under rigorous investigation with great hopes for advent of immunotherapy in oncology as well as other pathologies. So are the HSPs a breakthrough in therapy of cancers or will they be just another form of palliative treatment of these notorious and deadly diseases? HSPs is a family of proteins expressed virtually by all living organisms. These proteins have a number of functions that are crucial to organism's intracellular and extracellular homeostasis. Due to the significance of HSPs, over the eons of the evolution, they have been highly conserved in our genetic code. The human HSPs shares almost 50 percent homology with simple unicellular prokaryotes to well over 95 percent homology with higher species of living organisms. Despite of the fact that HSPs have been knows for approximately 50 years and despite of the intensive resears in the field, currently Russia is the only place where HSP immunotherapy has been approved as of 2008 for treatment in renal cell carcinoma. The HSPs immunotherapy has proven benefitial as an adjuvant treatment in some stages of a selected cancers. The advantage of HPSs immunotherapy is that it has less side effects compared to standart chemotherapy...en_US
uk.file-availabilityV
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, 3. lékařská fakulta, Gynekologicko porodnická klinika - oddělení molekulární biologie a patologie buňkycs_CZ
thesis.grade.code1


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