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Funkční genomika jaderných receptorů a jejich kofaktorů: Jaderné receptory propojují metabolismus a vývoj
dc.contributor.advisorKostrouch, Zdeněk
dc.creatorPohludka, Michal
dc.date.accessioned2018-09-18T10:03:28Z
dc.date.available2018-09-18T10:03:28Z
dc.date.issued2009
dc.identifier.urihttp://hdl.handle.net/20.500.11956/24384
dc.description.abstractThe aim of the study was to contribute to the understanding of regulatory functions of nuclear hormone receptors by studies focused on a group of multiplied nuclear receptors present in the genome of Caenorhabditis elegans, specifically nhr-40 and nhr-60. The work presented in this thesis was a part of an effort to characterize the selected nuclear receptors systematically by means of Caenorhabditis elegans functional genetics and genomics. Studies constituting this thesis were meant as an application of proteomics in the functional analysis of the selected nuclear receptors in the frame of the complex biology of Caenorhabditis elegans. The proteomic scope of this thesis was aimed at understanding of the selected receptors at the level of the protein, the protein nature, localization and dynamics as well as the proteomic characterization of the consequences of the protein loss of function.en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, 1. lékařská fakultacs_CZ
dc.titleFunctional genomics of nuclear hormone receptors and their cofactors: Connection between metabolism and development by diversified nematode nuclear hormone receptorsen_US
dc.typedizertační prácecs_CZ
dcterms.created2009
dcterms.dateAccepted2009-06-11
dc.description.departmentInstitute of Inherited Metabolic Disorders First Faculty of Medicine Charles University in Pragueen_US
dc.description.departmentÚstav dědičných metabolických poruch 1.LF a VFN v Prazecs_CZ
dc.description.facultyFirst Faculty of Medicineen_US
dc.description.faculty1. lékařská fakultacs_CZ
dc.identifier.repId71108
dc.title.translatedFunkční genomika jaderných receptorů a jejich kofaktorů: Jaderné receptory propojují metabolismus a vývojcs_CZ
dc.contributor.refereeMandys, Václav
dc.contributor.refereeRaška, Ivan
dc.identifier.aleph001125931
thesis.degree.namePh.D.
thesis.degree.leveldoktorskécs_CZ
thesis.degree.discipline-cs_CZ
thesis.degree.discipline-en_US
thesis.degree.programCell Biology and Pathologyen_US
thesis.degree.programBiologie a patologie buňkycs_CZ
uk.faculty-name.cs1. lékařská fakultacs_CZ
uk.faculty-name.enFirst Faculty of Medicineen_US
uk.faculty-abbr.cs1.LFcs_CZ
uk.degree-discipline.cs-cs_CZ
uk.degree-discipline.en-en_US
uk.degree-program.csBiologie a patologie buňkycs_CZ
uk.degree-program.enCell Biology and Pathologyen_US
thesis.grade.csProspěl/acs_CZ
thesis.grade.enPassen_US
uk.abstract.enThe aim of the study was to contribute to the understanding of regulatory functions of nuclear hormone receptors by studies focused on a group of multiplied nuclear receptors present in the genome of Caenorhabditis elegans, specifically nhr-40 and nhr-60. The work presented in this thesis was a part of an effort to characterize the selected nuclear receptors systematically by means of Caenorhabditis elegans functional genetics and genomics. Studies constituting this thesis were meant as an application of proteomics in the functional analysis of the selected nuclear receptors in the frame of the complex biology of Caenorhabditis elegans. The proteomic scope of this thesis was aimed at understanding of the selected receptors at the level of the protein, the protein nature, localization and dynamics as well as the proteomic characterization of the consequences of the protein loss of function.en_US
uk.file-availabilityV
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, 1. lékařská fakulta, Ústav dědičných metabolických poruch 1.LF a VFN v Prazecs_CZ
thesis.grade.codeP


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