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Chemokines and their receptors in pathogenesis of interstitial lung diseases
dc.contributor.advisorStříž, Ilja
dc.creatorŠterclová, Martina
dc.date.accessioned2018-09-18T09:08:54Z
dc.date.available2018-09-18T09:08:54Z
dc.date.issued2009
dc.identifier.urihttp://hdl.handle.net/20.500.11956/23932
dc.description.abstractSarcoidosis and extrinsic allergic alveolitis (EAA) are granulomatous lung diseases with predominantly Th1 immune response. In this prospective study, we analyzed the expression of chemokine receptors CXCR2, CXCR3 and CCR3 on bronchoalveolar lavage fluid (BALF) CD4 T-cells of patients either with EAA or sarcoidosis. We investigated the correlation of chemokine receptors expression, lymphocyte and neutrophil counts in BALF and high resolution tomography (HRCT) pattern. Thirteen sarcoidosis and 6 EAA patients were enrolled in the study. The expression of chemokine receptors on BALF CD4 T cells were analysed by flow cytometry. HRCT scoring system according to Kazerooni EA. was used for evaluation of the disease extent. We have found positive correlation between BALF CD4 T-cells CXCR3 expression and HRCT alveolar score in EAA patiens (p<0.01). CXCR2 expression on BALF CD4 T-cells and interstitial HRCT score did not show a correlation either in the EAA or the sarcoidosis group. Positive correlation between CCR3 expression on CD4+ T cells and HRCT interstitial score was proven in the EAA group (p<0.05). We conclude, that Th2 predominant immune response may play an important role in chronic EAA pathogenesis. The role of chemokine receptors in the pathogenesis of EAA and sarcoidosis should be presumed and investigated.en_US
dc.languageČeštinacs_CZ
dc.language.isocs_CZ
dc.publisherUniverzita Karlova, 1. lékařská fakultacs_CZ
dc.titleChemokiny a jejich receptory v patogenezi fibrotizujících plicních procesůcs_CZ
dc.typedizertační prácecs_CZ
dcterms.created2009
dcterms.dateAccepted2009-09-22
dc.description.departmentInstitute for Clinical and Experimental Medicineen_US
dc.description.departmentInstitut klinické a experimentální medicínycs_CZ
dc.description.facultyFirst Faculty of Medicineen_US
dc.description.faculty1. lékařská fakultacs_CZ
dc.identifier.repId69606
dc.title.translatedChemokines and their receptors in pathogenesis of interstitial lung diseasesen_US
dc.contributor.refereePosová, Helena
dc.contributor.refereeMusil, Jaromír
dc.identifier.aleph001444036
thesis.degree.namePh.D.
thesis.degree.leveldoktorskécs_CZ
thesis.degree.discipline-cs_CZ
thesis.degree.discipline-en_US
thesis.degree.programImmunologyen_US
thesis.degree.programImunologiecs_CZ
uk.thesis.typedizertační prácecs_CZ
uk.taxonomy.organization-cs1. lékařská fakulta::Institut klinické a experimentální medicínycs_CZ
uk.taxonomy.organization-enFirst Faculty of Medicine::Institute for Clinical and Experimental Medicineen_US
uk.faculty-name.cs1. lékařská fakultacs_CZ
uk.faculty-name.enFirst Faculty of Medicineen_US
uk.faculty-abbr.cs1.LFcs_CZ
uk.degree-discipline.cs-cs_CZ
uk.degree-discipline.en-en_US
uk.degree-program.csImunologiecs_CZ
uk.degree-program.enImmunologyen_US
thesis.grade.csProspěl/acs_CZ
thesis.grade.enPassen_US
uk.abstract.enSarcoidosis and extrinsic allergic alveolitis (EAA) are granulomatous lung diseases with predominantly Th1 immune response. In this prospective study, we analyzed the expression of chemokine receptors CXCR2, CXCR3 and CCR3 on bronchoalveolar lavage fluid (BALF) CD4 T-cells of patients either with EAA or sarcoidosis. We investigated the correlation of chemokine receptors expression, lymphocyte and neutrophil counts in BALF and high resolution tomography (HRCT) pattern. Thirteen sarcoidosis and 6 EAA patients were enrolled in the study. The expression of chemokine receptors on BALF CD4 T cells were analysed by flow cytometry. HRCT scoring system according to Kazerooni EA. was used for evaluation of the disease extent. We have found positive correlation between BALF CD4 T-cells CXCR3 expression and HRCT alveolar score in EAA patiens (p<0.01). CXCR2 expression on BALF CD4 T-cells and interstitial HRCT score did not show a correlation either in the EAA or the sarcoidosis group. Positive correlation between CCR3 expression on CD4+ T cells and HRCT interstitial score was proven in the EAA group (p<0.05). We conclude, that Th2 predominant immune response may play an important role in chronic EAA pathogenesis. The role of chemokine receptors in the pathogenesis of EAA and sarcoidosis should be presumed and investigated.en_US
uk.file-availabilityV
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, 1. lékařská fakulta, Institut klinické a experimentální medicínycs_CZ
thesis.grade.codeP


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