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Diagnostika neurodegenerativních chorob pomocí Ramanovy spektroskopie
Diagnostics of neurodegenerative diseases by means of Raman spectroscopy
diploma thesis
Advisor: Kopecký, Vladimír
Date Issued:
Date of defense: 30. 05. 2011
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: Léčba neurodegenerativních chorob je často velmi obtížná a její úspěšnost závisí na včasné diagnóze. Proto jsme v této práci vyvíjeli novou diagnostickou metodu roztroušené sklerózy a Alzheimerovy nemoci pomocí Ramanovy ...
Therapies of neurodegenerative diseases are often very difficult and their success depend on an early diagnose. From that reason we have been developing new diagnostic method for multiple sclerosis and Alzheimer disease ...
Therapies of neurodegenerative diseases are often very difficult and their success depend on an early diagnose. From that reason we have been developing new diagnostic method for multiple sclerosis and Alzheimer disease ...
Studium biomolekul pomocí povrchem zesílené Ramanovy mikrospektroskopie
Study of biomolecules by Surface-enhanced Raman microspectroscopy
diploma thesis
Advisor: Procházka, Marek
Date Issued:
Date of defense: 14. 09. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: Práce se zabývá studiem biomolekul pomocí mikrospektroskopie povrchem zesíleného Ramanova rozptylu (SERS). K tomuto účelu byly testovány povrchy na bázi zlatých a stříbrných koloidních nanočástic imobilizovaných buď pomocí ...
This work deals with study of biomolecules using surface-enhanced Raman scattering (SERS) microspectroscopy. For that purpose surfaces based on gold and silver colloidal nanoparticles immobilized either by silane or by ...
This work deals with study of biomolecules using surface-enhanced Raman scattering (SERS) microspectroscopy. For that purpose surfaces based on gold and silver colloidal nanoparticles immobilized either by silane or by ...
Mikrokalorimetrické studium termodynamické stability hybridních komplexů nukleových kyselin
Thermodynamic Stability of Hybrid Nucleic Acid Complexes: Microcalorimetric Study
diploma thesis
Advisor: Štěpánek, Josef
Date Issued:
Date of defense: 14. 09. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: Práce se zabývá aplikací diferenční skenovací kalorimetrie (DSC) pro studium potenciálních oligonukleotidových terapeutik. Byly stanoveny možnosti i limity použitého DSC přístroje a stanovené optimální podmínky pro měření ...
This work deals with implementation of differential scanning kalorimetry (DSC) into research of potential oligonucleotide therapeutics. Capabilities and limits of the DSC device have been determined and optimal conditions ...
This work deals with implementation of differential scanning kalorimetry (DSC) into research of potential oligonucleotide therapeutics. Capabilities and limits of the DSC device have been determined and optimal conditions ...
Strukturní flexibilita regulačního segmentu DNA
Structural flexibility of regulatory DNA element
diploma thesis
Advisor: Štěpánek, Josef
Date Issued:
Date of defense: 14. 09. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: Transcription of the genetic code is controlled by numerous proteins. Some of them, so-called transcription factors, bind to certain DNA regions possessing anomalous properties due to their specific and highly conservative ...
Molekulárně-dynamické simulace komplexů sestávajících z proteinů a nukleových kyselin
Molecular dynamics simulations of complexes consisting of proteins and nucleic acids
diploma thesis
Advisor: Barvík, Ivan
Date Issued:
Date of defense: 20. 05. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: V rámci diplomová práce byly prostudovány algoritmy numerické integrace. Poté byla provedena důkladná studie aktivních míst polymeras virů HCV a HIV v komplexech s přirozeným substrátem a komplexem, ve kterém byl přistupující ...
At first, numerical integration algorithms was studied. Main objective was a study of active sites of HCV and HIV polymerases in complexes with a natural substrate and in complexes where an approaching nucleosidetriphosphate ...
At first, numerical integration algorithms was studied. Main objective was a study of active sites of HCV and HIV polymerases in complexes with a natural substrate and in complexes where an approaching nucleosidetriphosphate ...
Metabolický profil lidského mozku in vivo v MR obraze a spektru
Metabolic profile of human brain in vivo in MR image and spectrum
diploma thesis
Advisor: Hájek, Milan
Date Issued:
Date of defense: 11. 09. 2007
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: Magnetic resonance imaging and spectroscopic imaging have proven to be useful to monitor a metabolism in the human brain. The thesis is concerned to repeatability and reproducibility of spectroscopic data measured on 1.5T ...
Molekulárně-dynamické simulace komplexů nukleových kyselin enzymu RNase H
MD simulations of complexes between nucleic acids and RNase H
diploma thesis
Advisor: Barvík, Ivan
Date Issued:
Date of defense: 25. 05. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: The aim of this diploma thesis was to study interactions between human Rase H enzyme and a natural and modified substrate using molecular dynamics simulations (altogether 9 MD runs ere produced). Conformational preferences ...
Studium transportních proteinů z rodiny Nramp
Study of transport proteins of the Nramp family
diploma thesis
Advisor: Chaloupka, Roman
Date Issued:
Date of defense: 25. 05. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: The Natural Resistance-Associated Macrophage Proteins (Nramp) form functionally conserved family of proton-dependent divalent metal ion transporters. In the present study, we investigated transport properties of a prokaryotic ...
Fotoelektrický transport ve vysokoodporovém CdTe pro detektory rentgenova záření
Photoelectric transport in high resistivity CdTe for gamma ray detectors
diploma thesis
Advisor: Franc, Jan
Date Issued:
Date of defense: 22. 09. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: CdTe semiconductor is a good material for the construction of X-ray and gamma ray detectors. Its physical properties are strongly influenced by an existence of deep levels in the forbidden band. This thesis deals with an ...
Přenos koherencí při relaxaci excitační energie v molekulárních agregátech
Coherence transfer during relaxation in molecular aggregates
diploma thesis
Advisor: Mančal, Tomáš
Date Issued:
Date of defense: 15. 05. 2009
Faculty / Institute: Matematicko-fyzikální fakulta / Faculty of Mathematics and Physics
Abstract: Předložená práce zkoumá časový vývoj operátoru hustoty agregátů molekul v interakci s termodynamickou lázní s účelem najít vhodnou aproximaci pro popis vlivu přenosu koherencí na tento vývoj. Opírá se o výsledky autorem ...
We study the time dependence of the density operator of molecular aggregates in contact with thermal bath, to find a proper approximation for the description of a coherence transfer influence on this evolution. It is based ...
We study the time dependence of the density operator of molecular aggregates in contact with thermal bath, to find a proper approximation for the description of a coherence transfer influence on this evolution. It is based ...