Přírodovědecká fakulta: Recent submissions
Now showing items 1-20 of 32958
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Syntéza a koordinační vlastnosti difenylfosfinoferrocifenu
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 16. 7. 2026Název práce: Syntéza a koordinační vlastnosti difenylfosfinoferrocifenu Autorka: Bc. Magda Křelinová Katedra: Katedra anorganické chemie Vedoucí diplomové práce: RNDr. Jiří Schulz, Ph.D. Abstrakt: Ferrocifen, jakožto ... -
Karyotype evolution of selected Polyneoptera lineages
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 14. 7. 2026The Polyneoptera group comprises ten insect orders exhibiting immense variability in morphology, life-strategies, karyotypes and genome organization. Some of the orders have been shown to significantly differ in karyotype ... -
Cyklometalace fenylpyridinů s ferrocenylovým substituentem
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 16. 7. 2026Title: Cyclometalation of phenylpyridines with a ferrocenyl group Author: Bc. Petr Harmach Department: Katedra anorganické chemie Supervisor: prof. RNDr. Petr Štěpnička, Ph.D., DSc. Abstract: The objective of this thesis ... -
Příprava P,N-donorových ferrocenových ligandů pomocí spojovacích reakcí
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 16. 7. 2026Title: Preparation of P,N-donor ferrocene ligands by coupling reactions Author: Bc. David Rezazgui Department: Department of Inorganic Chemistry Supervisor: RNDr. Jiří Schulz, Ph.D. Abstract: P,N-donor ligands form a varied ... -
Příprava anelovaných ferrocenových sloučenin C-H aktivací
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 16. 7. 2026Title: Synthesis of annelated ferrocene compounds by C-H activation Author: Věra Varmužová Department: Department of Inorganic chemistry Supervisor: prof. RNDr. Petr Štěpnička, Ph.D., DSc. Abstract: This diploma thesis ... -
Ferocénové stibánové ligandy
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 16. 7. 20265 Title: Ferrocene stibane ligands Author: Jakub Antala Department: Department of Inorganic Chemistry Supervisor: prof. RNDr. Petr Štěpnička, Ph.D., DSc. Abstract: This diploma thesis reports a study into the coordination ... -
Role of extracellular matrix in the regulation of cellular functions in nervous tissue
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 1. 6. 2026Extracellular matrix rich in hyaluronan contributes to nervous tissue homeostasis, yet the tissue consequences of chronic pharmacological hyaluronan depletion in the healthy spinal cord remain insufficiently defined. This ... -
Postoje tuniských obyvatel k imigraci a imigrantům
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 3. 6. 2026This thesis analyses attitudes of Tunisian population towards immigration and immigrants and tests the relevance of standard theoretical approaches explaining the formation of these attitudes in a non-Western context. The ... -
Extended study of the 5-aminotetrazole potential for the preparation of new crystalline materials for applications in nonlinear optics
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 11. 6. 2026This diploma thesis focuses on the assessment of the potential of individ- ual forms of 5-aminotetrazole and their compounds for applications in nonlin- ear optics. The study combines quantum chemical calculations with ... -
Tumor suppressors of tumor cell migration and invasion
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 3. 6. 2026Metastasis is a complex process and the leading cause of cancer mortality, heavily reliant on actin cytoskeleton reorganization. The Rho family of small GTPases serves as the central regulator of actin dynamics, controlling ... -
Genetické a environmentální faktory ovlivňující vznik polyploidních mutantů v rostlinných populacích
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 28. 5. 2026Polyploid mutants arise repeatedly and independently in natural plant populations in every generation. The mechanisms underlying their formation include polyploidization via unreduced (2n) gametes, somatic polyploidization, ... -
Porucha funkce cirkadiánních hodin s dopadem na rozvoj diabetu 2. typu
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 28. 5. 2026Organisms are able to adapt their physiological processes to the regular alternation of day and night. In mammals, this time-keeping system consists of central circadian clocks located in the suprachiasmatic nuclei of the ... -
Circadian Regulation of Energy Balance in the Brain: The Role of Tanycytes
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 5. 6. 2026Tanycyty jsou specializované gliové buňky, které hrají důležitou roli v regulaci metabolické homeostázy v mozku. V posledních desetiletích přitahují stále více pozornost zejména v souvislosti s metabolickými poruchami, ... -
Hospodářský význam opylujících pestřenek (Diptera: Syrphidae)
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 3. 6. 2026Pollination is essential for the reproduction of the vast majority of plants. Although this role is often attributed primarily to bees, wild pollinators are also of enormous importance. These include hoverflies (Diptera: ... -
Regenerace a zmlazení invazní vejmutovky v NP České Švýcarsko a CHKO Labské pískovce
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 25. 5. 2026Invasive plants cause a range of negative conservation and economic impacts. Since the establishment of the Bohemian Switzerland National Park, efforts have been made to address the invasion of eastern white pine, which ... -
Regulace mTORC2 dráhy v oocytu
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 2. 6. 2026This thesis focuses on the role of the mTORC2 signalling pathway during meiotic maturation of mammalian oocytes. The aim of this study was to analyse the role of mTORC2 in oocyte maturation and developmental competence. ... -
Cílená mutageneze glykosidas a analýza jejich substrátové specifity
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 9. 6. 2026Enzymatically catalysed transglycosylation represents an effective strategy for the synthesis of complex carbohydrates. Compared to classical methods of organic synthesis, enzymatic catalysis offers higher selectivity, ... -
Studium molekulárního mechanismu regulace E3 ubikvitinligas z Nedd4 rodiny pomocí proteinu Ndfip2
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 9. 6. 2026Nedd4-2 is an important human ubiquitin ligase belonging to the Nedd4 HECT family. Its structure consists of three core domains: a calcium-dependent C2 domain, four WW domains involved in protein-protein interactions, and ... -
Vliv hemu na strukturu a enzymovou aktivitu pyruvátkinázy M2
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 9. 6. 2026This diploma thesis deals with the interaction between heme and pyruvate kinase M2, an important glycolytic enzyme involved in the regulation of cellular metabolism. The main aim of this thesis was to characterize the ... -
Vývoj a validace UHPLC metody pro současné stanovení Candesartanu a Lercanidipinu a jejich degradačních produktů v kombinovaném léčivém přípravku
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2026)Date of defense: 28. 5. 2026This diploma thesis is focused on the development of a UHPLC method for the simultaneous determination of Candesartan cilexetil and Lercanidipine hydrochloride including their degradation impurities in bilayer tablets. The ...