Search
Now showing items 1-10 of 1415
Purifikace a charakterizace penicilin-G-acylasy izolované z rekombinantní Pichia pastoris X33 (pPICPA1) a z donorového kmene Escherichia coli RE3
Purification and characterization of penicillin G acylase isolated from recombinant Pichia pastoris X33 (pPICPA1) and donor strain Escherichia coli RE3
diploma thesis (DEFENDED)
Advisor: Kyslík, Pavel
Date Issued: 2007
Date of defense: 29. 05. 2007
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract not found
The preparation and characterisation of analogues of insulin and IGF-2 selective for both isoform of insulin receptor and IGF-1 receptor
Příprava a charakterizace selektivních analogů insulinu a IGF-2 pro obě isoformy insulinového receptoru a IGF-1 receptoru
dissertation thesis (DEFENDED)
Advisor: Žáková, Lenka
Date Issued: 2019
Date of defense: 17. 12. 2019
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract: Insulin a insulinu podobné růstové faktory 1 (IGF 2) jsou příbuzné proteinové rozdílnými, avšak překrývajícími se biologickými funkcemi. Všechny tři hormony interagují, i když s různou afinitou, s receptory, patřící do ...
Insulin and insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) are related protein hormones with different but overlapping biological functions. All the hormones interact with a receptor within the insulin-IGF system ...
Insulin and insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) are related protein hormones with different but overlapping biological functions. All the hormones interact with a receptor within the insulin-IGF system ...
Studium enantioselektivity a syntézy β-laktamových antibiotik katalyzované penicilin G acylasou: biokatalýza a in-silico experimenty
Study enantioselectivity and synthesis of β-lactam antibiotics catalyzed by penicilin G acylase: Biocatalysis and in-silico experiments
dissertation thesis (DEFENDED)
Advisor: Kyslík, Pavel
Date Issued: 2015
Date of defense: 09. 12. 2015
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract: 10 Abstrakt Penicilin-G-acylasy (PGA) se řadí mezi enantioselektivní enzymy katalyzující hydrolýzu stabilní amidické vazby v rámci širokého spektra substrátů majících často velký aplikační potenciál. PGA z mikroorganismů ...
11 Abstract Penicillin G acylases (PGAs) belong among enantioselective enzymes catalyzing a hydrolysis of stable amide bond in a broad spectrum of substrates, often having high application potential. PGAEc from Escherichia ...
11 Abstract Penicillin G acylases (PGAs) belong among enantioselective enzymes catalyzing a hydrolysis of stable amide bond in a broad spectrum of substrates, often having high application potential. PGAEc from Escherichia ...
Optimalizace exprese fotoaktivovatelných cytochromů P450 jako nano-sond pro studium membránové topologie enzymů metabolismu léčiv a aktivace karcinogenů
Optimalization of expression of photoactivatable cytochrome P450 as a nano-probe for the membrane topology studies of enzymes metabolizing drugs and carcinogens
bachelor thesis (DEFENDED)
Advisor: Hodek, Petr
Date Issued: 2013
Date of defense: 11. 06. 2013
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract: Cytochromy P450 patří mezi jedny z nejdůležitějších enzymů podílejících se na biotransformaci cizorodých látek v organismu. Jsou součástí tzv. moooxygenasového systému, ve kterém interagují s dalšími enzymy - NADPH:cytochrom ...
The cytochromes P450 are among the most important enzymes involved in the biotransformation of xenobiotics in the body. They are part of the moooxygenase system that interact with other enzymes - NADPH:cytochrome P450 ...
The cytochromes P450 are among the most important enzymes involved in the biotransformation of xenobiotics in the body. They are part of the moooxygenase system that interact with other enzymes - NADPH:cytochrome P450 ...
Role iontů železa v metabolismu améby Naegleria gruberi
The role of iron in the metabolism of the amoeba Naegleria gruberi
bachelor thesis (DEFENDED)
Advisor: Konvalinka, Jan
Date Issued: 2016
Date of defense: 06. 09. 2016
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract: Železo je biogenní stopový prvek, jehož dostupnost je pro organismy životně důležitá. V biologických systémech se vyskytuje železo ve formě iontů Fe2+ a Fe3+ , které jsou většinou inkorporovány do struktury hemu nebo ...
Iron is a biogenic trace element that is vital for all organisms on the planet Earth. This element occurs in biological systems in the form of Fe3+ and Fe2+. These two forms are often incorporated in heme structures or ...
Iron is a biogenic trace element that is vital for all organisms on the planet Earth. This element occurs in biological systems in the form of Fe3+ and Fe2+. These two forms are often incorporated in heme structures or ...
Polymorfismy genu PXR v české populaci
Polymorphisms of PXR gene in Czech population
diploma thesis (DEFENDED)
Advisor: Perlík, František
Date Issued: 2006
Date of defense: 29. 05. 2006
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract not found
Metabolismus inhibitorů tyrosinkinas, protinádorových léčiv nové generace
Metabolism of inhibitors of tyrosine kinases, the drugs of new generation
bachelor thesis (DEFENDED)
Advisor: Indra, Radek
Date Issued: 2020
Date of defense: 15. 09. 2020
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract: Nádorová onemocnění jsou po infarktu myokardu druhou nejčastější příčinou úmrtí ve světě. V posledních letech se výzkum v rámci cílené chemoterapeutické léčby zaměřil na inhibitory tyrosinkinas. Vandetanib je tyrosinkinasový ...
Cancer is the second major cause of death after heart-attack in the world. In recent years, research has focused on tyrosine kinase inhibitors (TKIs) as part of targeted chemotherapeutic treatment. Vandetanib is a TKI ...
Cancer is the second major cause of death after heart-attack in the world. In recent years, research has focused on tyrosine kinase inhibitors (TKIs) as part of targeted chemotherapeutic treatment. Vandetanib is a TKI ...
Fytohormony produkované askomycetou Leptosphaeria maculans jako efektory ovlivňující signální dráhy rostlin
Phytohormones produced by Leptosphaeria maculans as effectors manipulating plant signaling pathways
diploma thesis (DEFENDED)
Advisor: Ryšlavá, Helena
Date Issued: 2014
Date of defense: 08. 09. 2014
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract: Leptosphaeria maculans je patogenní houba způsobující fómové černání stonků řepky Brassica napus. V rámci této práce bylo zjištěno, že L. maculans produkuje in vitro řadu fytohormonů a dále se soustředila se na auxiny a ...
Leptosphaeria maculans is the causal agent of blackleg disease in Brassica napus. In this thesis the ability of L. maculans to produce certain phytohormones was established. The thesis focused on auxins and brassinosteroids. ...
Leptosphaeria maculans is the causal agent of blackleg disease in Brassica napus. In this thesis the ability of L. maculans to produce certain phytohormones was established. The thesis focused on auxins and brassinosteroids. ...
Inhibice purinnukleosidfosforylasy acyklickými nukleosidfosfonáty
Purine nucleoside phosphorylase inhibition by acyclic nucleoside phosphonates
diploma thesis (DEFENDED)
Advisor: Votruba, Ivan
Date Issued: 2006
Date of defense: 30. 05. 2006
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract not found
Studium vybraných aspektů modifikace proteinů pomocí β-N-acetylglukosaminu
Study of selected apects of protein modification by β-N-acetylglucosamine
diploma thesis (DEFENDED)
Advisor: Hansíková, Hana
Date Issued: 2019
Date of defense: 21. 05. 2019
Faculty / Institute: Přírodovědecká fakulta / Faculty of Science
Abstract: O-glykosylace pomocí β-N-acetylglukosaminu (O-GlcNAc) je posttranslační modifikace proteinů, regulovaná β-N-acetylglukosaminyltransferasou (OGT) a β-N-acetylglukosaminidasou (OGA). Tato intracelulární glykosylace se podstatně ...
Glycosylation O-linked β-N-acetylglucosamine (O-GlcNAc) is post-translational modification of proteins, regulated by β-N-acetylglucosaminyltransferase (OGT) and β-N-acetylglucosaminidase (OGA). This intracellular glycosylation ...
Glycosylation O-linked β-N-acetylglucosamine (O-GlcNAc) is post-translational modification of proteins, regulated by β-N-acetylglucosaminyltransferase (OGT) and β-N-acetylglucosaminidase (OGA). This intracellular glycosylation ...