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The correlation of intracranial pressure and next investigative parameters at the cerebral contusion
dc.contributor.advisorChoc, Milan
dc.creatorŠkúci, Ivan
dc.date.accessioned2018-11-26T14:44:05Z
dc.date.available2018-11-26T14:44:05Z
dc.date.issued2007
dc.identifier.urihttp://hdl.handle.net/20.500.11956/13950
dc.description.abstractPatients with a brain injury must overcome a central neurological insult and a systematic metabolic response. The systematic response includes hypermetabolism, hypercatabolism, altered vascular permeability, increased hormone and cytokine release, altered gastric emptying, altered mineral metabolism and altered immune status. This response may initiate mechanisms which lead to secondary brain injury and may adversely affect the function of other organs. Last two decades have improved our knowledge of pathophysiology in patients with primary and secondary brain injury including traumatic contusions. In a moment of injury, primary brain injury which is traumatic contusion can not be therapeutically prevented it can only have a preventive effect. Secondary brain injury can be therapeutically affected although both types of injuries have common pathophysiological signs of disturbed metabolism on cells and subcellular level. Research methods based on molecular biology opens a new zone of research reaction of central neurological system for trauma or ischemia with effort to get involved immediately at the beginning of developing adverse pathophysiological cascade leading to a death of neurotic cell. The brain contusion is a primary centre of brain injury with anatomic changes which can be graphically proved. In...en_US
dc.description.abstractAutor se ve své práci zabývá centrálním neurologickým postižením a systémovou metabolickou reakcí u pacientů po poranění mozku. Systémová odpověď zahrnuje hypermetabolizmus, hyperkatabolizmus, změněnou cévní prostupnost, rostoucí uvolnění hormonů a cytokinů, změněné gastrální vyprazdňování, minerální a glukózový metabolizmus a imunitní stav. Autor zahrnul do studie 51 pacientů s kontuzí mozku se vstupní poruchou vědomí.cs_CZ
dc.languageČeštinacs_CZ
dc.language.isocs_CZ
dc.publisherUniverzita Karlova, Lékařská fakulta v Plznics_CZ
dc.subjectCEREBRAL CONTUSIONen_US
dc.subjectINTRACRANIAL PRESSUREen_US
dc.subjectkontuze mozkucs_CZ
dc.subjectintrakraniální tlakcs_CZ
dc.titleKorelace intrakraniálního tlaku a dalších vyšetřovaných parametrů u kontuzí mozkucs_CZ
dc.typedizertační prácecs_CZ
dcterms.created2007
dcterms.dateAccepted2007-09-24
dc.description.departmentNeurochirurgická klinikacs_CZ
dc.description.facultyLékařská fakulta v Plznics_CZ
dc.description.facultyFaculty of Medicine in Pilsenen_US
dc.identifier.repId149070
dc.title.translatedThe correlation of intracranial pressure and next investigative parameters at the cerebral contusionen_US
dc.contributor.refereeNovák, Zdeněk
dc.contributor.refereeSmrčka, Martin
dc.identifier.aleph001712345
thesis.degree.namePh.D.
thesis.degree.leveldoktorskécs_CZ
thesis.degree.discipline-en_US
thesis.degree.discipline-cs_CZ
thesis.degree.programSurgeryen_US
thesis.degree.programChirurgiecs_CZ
uk.faculty-name.csLékařská fakulta v Plznics_CZ
uk.faculty-name.enFaculty of Medicine in Pilsenen_US
uk.faculty-abbr.csLFPcs_CZ
uk.degree-discipline.cs-cs_CZ
uk.degree-discipline.en-en_US
uk.degree-program.csChirurgiecs_CZ
uk.degree-program.enSurgeryen_US
thesis.grade.csProspěl/acs_CZ
thesis.grade.enPassen_US
uk.abstract.csAutor se ve své práci zabývá centrálním neurologickým postižením a systémovou metabolickou reakcí u pacientů po poranění mozku. Systémová odpověď zahrnuje hypermetabolizmus, hyperkatabolizmus, změněnou cévní prostupnost, rostoucí uvolnění hormonů a cytokinů, změněné gastrální vyprazdňování, minerální a glukózový metabolizmus a imunitní stav. Autor zahrnul do studie 51 pacientů s kontuzí mozku se vstupní poruchou vědomí.cs_CZ
uk.abstract.enPatients with a brain injury must overcome a central neurological insult and a systematic metabolic response. The systematic response includes hypermetabolism, hypercatabolism, altered vascular permeability, increased hormone and cytokine release, altered gastric emptying, altered mineral metabolism and altered immune status. This response may initiate mechanisms which lead to secondary brain injury and may adversely affect the function of other organs. Last two decades have improved our knowledge of pathophysiology in patients with primary and secondary brain injury including traumatic contusions. In a moment of injury, primary brain injury which is traumatic contusion can not be therapeutically prevented it can only have a preventive effect. Secondary brain injury can be therapeutically affected although both types of injuries have common pathophysiological signs of disturbed metabolism on cells and subcellular level. Research methods based on molecular biology opens a new zone of research reaction of central neurological system for trauma or ischemia with effort to get involved immediately at the beginning of developing adverse pathophysiological cascade leading to a death of neurotic cell. The brain contusion is a primary centre of brain injury with anatomic changes which can be graphically proved. In...en_US
uk.file-availabilityV
uk.publication.placePlzeňcs_CZ
uk.grantorUniverzita Karlova, Lékařská fakulta v Plzni, Neurochirurgická klinikacs_CZ
thesis.grade.codeP


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