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není uveden
dc.contributor.advisorVyoral, Daniel
dc.creatorBabušiak, Marek
dc.date.accessioned2018-09-18T08:32:51Z
dc.date.available2018-09-18T08:32:51Z
dc.date.issued2007
dc.identifier.urihttp://hdl.handle.net/20.500.11956/12748
dc.description.abstractThis thesis, The Biochemistry of Zinc and Iron - Proteomic Studies, consists of five sections. We were studying the biochemistry of two different metal elements - iron and zinc, therefore the thesis has two main aims (iron and zinc related) and each of the experimental sections are divided into two logical subsections A and B. The first section - Introduction includes a general introduction reviewing the current knowledge about the biochemistry of iron and zinc and it also specifies the objectives of this study. The first part of the Introduction is a review of iron biochemistry. It has following seven chapters: General properties of iron; Iron absorption, storage and toxicity in human; Iron transport and homeostasis; Iron regulatory proteins - IRP/IRE system; Mitochondrial iron metabolism; Liver and iron and Iron disorders. In the second part of the Introduction, the biochemistry of zinc is reviewed in these eight chapters: Zinc - general properties; Zinc transporters; Zinc finger proteins; The role of zinc fingers in leukemogenesis; Functions of zinc in cellular signalling; Regulatory functions of zinc in cell proliferation; Role for Zinc in cell differentiation and apoptosis; Zinc - remarks and perspectives. The third part of the Introduction introduces the specific objectives of this thesis. It gives a...en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, 1. lékařská fakultacs_CZ
dc.titleThe Biochemistry of Zine and Iron Proteomic Studiesen_US
dc.typedizertační prácecs_CZ
dcterms.created2007
dcterms.dateAccepted2007-09-19
dc.description.departmentInstitute of Clinical and Experimental Haematology First Faculty of Medicineen_US
dc.description.departmentÚstav klinické a experimentální hematologie 1. LF UK v Praze a ÚHKTcs_CZ
dc.description.facultyFirst Faculty of Medicineen_US
dc.description.faculty1. lékařská fakultacs_CZ
dc.identifier.repId126916
dc.title.translatednení uvedencs_CZ
dc.contributor.refereeHrkal, Zbyněk
dc.contributor.refereeČerný, Jan
dc.identifier.aleph000971215
thesis.degree.namePh.D.
thesis.degree.leveldoktorskécs_CZ
thesis.degree.discipline-cs_CZ
thesis.degree.discipline-en_US
thesis.degree.programBiochemistry and Pathobiochemistryen_US
thesis.degree.programBiochemie a patobiochemiecs_CZ
uk.faculty-name.cs1. lékařská fakultacs_CZ
uk.faculty-name.enFirst Faculty of Medicineen_US
uk.faculty-abbr.cs1.LFcs_CZ
uk.degree-discipline.cs-cs_CZ
uk.degree-discipline.en-en_US
uk.degree-program.csBiochemie a patobiochemiecs_CZ
uk.degree-program.enBiochemistry and Pathobiochemistryen_US
thesis.grade.csProspěl/acs_CZ
thesis.grade.enPassen_US
uk.abstract.enThis thesis, The Biochemistry of Zinc and Iron - Proteomic Studies, consists of five sections. We were studying the biochemistry of two different metal elements - iron and zinc, therefore the thesis has two main aims (iron and zinc related) and each of the experimental sections are divided into two logical subsections A and B. The first section - Introduction includes a general introduction reviewing the current knowledge about the biochemistry of iron and zinc and it also specifies the objectives of this study. The first part of the Introduction is a review of iron biochemistry. It has following seven chapters: General properties of iron; Iron absorption, storage and toxicity in human; Iron transport and homeostasis; Iron regulatory proteins - IRP/IRE system; Mitochondrial iron metabolism; Liver and iron and Iron disorders. In the second part of the Introduction, the biochemistry of zinc is reviewed in these eight chapters: Zinc - general properties; Zinc transporters; Zinc finger proteins; The role of zinc fingers in leukemogenesis; Functions of zinc in cellular signalling; Regulatory functions of zinc in cell proliferation; Role for Zinc in cell differentiation and apoptosis; Zinc - remarks and perspectives. The third part of the Introduction introduces the specific objectives of this thesis. It gives a...en_US
uk.file-availabilityV
uk.publication.placePrahacs_CZ
uk.grantorUniverzita Karlova, 1. lékařská fakulta, Ústav klinické a experimentální hematologie 1. LF UK v Praze a ÚHKTcs_CZ
thesis.grade.codeP


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