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Formulace a charakterizace PLGA nanočástic s oximy
dc.contributor.advisorŠnejdrová, Eva
dc.creatorHafezi, Ramin
dc.date.accessioned2021-06-24T08:52:29Z
dc.date.available2021-06-24T08:52:29Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/20.500.11956/126182
dc.description.abstractThesis title: Formulation and characterization of oxime loaded PLGA nanoparticles Author: Ramin Hafezi Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Advisor: PharmDr. Juraj Martiška, Ph.D. Department: Department of Pharmaceutical Technology The diploma thesis was focused on PLGA nanoparticles (NPs) which could be loaded with oximes, prepared by a double emulsion technique, and characterised by size, polydispersity and zeta potential. The theoretical part deals with the most common methods of the NPs preparation, the polymers and stabilizers employed, and drug delivery to brain. In the experimental part the effect of various formulation factors on NP characteristics were studied: linear or branched PLGA derivative, the concentrations of polymer, the volumes of primary emulsion. Dichloromethane (DCM) or Dimethyl sulfoxide (DMSO) as solvent for polymers were used and Poloxamer 407 or Didodecyldimethylammonium bromide (DDAB) as an outer phase stabilizer were employed. By comparison among the collected results, it seemed 1% A2 in DMSO and stabilization with poloxamer 407 could be best candidate for the oxime loaded drug delivery systems as it was possible to produce nanoparticles with size from 152 to 168 nm with PDI of below 0.15. Electrostatic stability in case of using DDAB was resulted excellent and...en_US
dc.languageEnglishcs_CZ
dc.language.isoen_US
dc.publisherUniverzita Karlova, Farmaceutická fakulta v Hradci Královécs_CZ
dc.subjectnanoparticlesen_US
dc.subjectrifampicinen_US
dc.subjectparticles sizeen_US
dc.subjectzeta potentialen_US
dc.subjectencapsulation efficiencyen_US
dc.subjectdissolutionen_US
dc.subjectnanočásticecs_CZ
dc.subjectrifampicincs_CZ
dc.subjectvelikost částiccs_CZ
dc.subjectzeta potenciálcs_CZ
dc.subjectenkapsulační účinnostcs_CZ
dc.subjectdisolucecs_CZ
dc.titleFormulation and characterization of oxims loaded PLGA nanoparticlesen_US
dc.typediplomová prácecs_CZ
dcterms.created2021
dcterms.dateAccepted2021-06-02
dc.description.departmentDepartment of Pharmaceutical Technologyen_US
dc.description.departmentKatedra farmaceutické technologiecs_CZ
dc.description.facultyFaculty of Pharmacy in Hradec Královéen_US
dc.description.facultyFarmaceutická fakulta v Hradci Královécs_CZ
dc.identifier.repId217251
dc.title.translatedFormulace a charakterizace PLGA nanočástic s oximycs_CZ
dc.contributor.refereeParaskevopoulos, Georgios
thesis.degree.nameMgr.
thesis.degree.levelmagisterskécs_CZ
thesis.degree.disciplineFarmaciecs_CZ
thesis.degree.disciplinePharmacyen_US
thesis.degree.programPharmacyen_US
thesis.degree.programFarmaciecs_CZ
uk.thesis.typediplomová prácecs_CZ
uk.taxonomy.organization-csFarmaceutická fakulta v Hradci Králové::Katedra farmaceutické technologiecs_CZ
uk.taxonomy.organization-enFaculty of Pharmacy in Hradec Králové::Department of Pharmaceutical Technologyen_US
uk.faculty-name.csFarmaceutická fakulta v Hradci Královécs_CZ
uk.faculty-name.enFaculty of Pharmacy in Hradec Královéen_US
uk.faculty-abbr.csFaFcs_CZ
uk.degree-discipline.csFarmaciecs_CZ
uk.degree-discipline.enPharmacyen_US
uk.degree-program.csFarmaciecs_CZ
uk.degree-program.enPharmacyen_US
thesis.grade.csVelmi dobřecs_CZ
thesis.grade.enVery gooden_US
uk.abstract.enThesis title: Formulation and characterization of oxime loaded PLGA nanoparticles Author: Ramin Hafezi Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Advisor: PharmDr. Juraj Martiška, Ph.D. Department: Department of Pharmaceutical Technology The diploma thesis was focused on PLGA nanoparticles (NPs) which could be loaded with oximes, prepared by a double emulsion technique, and characterised by size, polydispersity and zeta potential. The theoretical part deals with the most common methods of the NPs preparation, the polymers and stabilizers employed, and drug delivery to brain. In the experimental part the effect of various formulation factors on NP characteristics were studied: linear or branched PLGA derivative, the concentrations of polymer, the volumes of primary emulsion. Dichloromethane (DCM) or Dimethyl sulfoxide (DMSO) as solvent for polymers were used and Poloxamer 407 or Didodecyldimethylammonium bromide (DDAB) as an outer phase stabilizer were employed. By comparison among the collected results, it seemed 1% A2 in DMSO and stabilization with poloxamer 407 could be best candidate for the oxime loaded drug delivery systems as it was possible to produce nanoparticles with size from 152 to 168 nm with PDI of below 0.15. Electrostatic stability in case of using DDAB was resulted excellent and...en_US
uk.file-availabilityV
uk.grantorUniverzita Karlova, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologiecs_CZ
thesis.grade.code2
dc.contributor.consultantMartiška, Juraj
uk.publication-placeHradec Královécs_CZ
uk.thesis.defenceStatusO


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