Browsing by Author "Václavková, Vendula"
Now showing items 1-2 of 2
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Genetická a molekulární podstata Meckel-Gruberova syndromu
Defence status: DEFENDEDVáclavková, Vendula (Univerzita Karlova, Přírodovědecká fakulta, 2020)Date of defense: 10. 7. 2020Meckel-Gruber syndrome (MKS) is rare multisystemic, autosomal recessive hereditary disorder, which appears in different places around the world. MKS is classified as a ciliopathy. These disorders are caused by defects of ... -
Influence of lamin A/C on paternal pronucleus DNA demethylation
Defence status: DEFENDEDVáclavková, Vendula (Univerzita Karlova, Přírodovědecká fakulta, 2022)Date of defense: 7. 6. 2022A series of dynamic epigenetic changes need to happen to rebuild the gamete's genome after fertilization and to secure the totipotency of the zygote. The processes can be observed in both parental pronuclei, although the ...