• Expression and function of serpin B9 in lung carcer cells 

      Defence status: DEFENDED
      Roušalová, Ilona (Univerzita Karlova, 3. lékařská fakulta, 2012)
      Date of defense: 12. 9. 2012
      Background: Granzyme B (GrB) is a key proapoptotic secretory protease of CTLs and NK cells. Its specific proapoptotic effects in cancer cells can be blocked by increased expression of serpinB9. SerpinB9 gene expression can ...
    • Expression of apoptosome pathway regulators and activation of apoptosome apparatus in non-small cell lung carcinoma 

      Defence status: DEFENDED
      Moravčíková, Erika (Univerzita Karlova, 3. lékařská fakulta, 2013)
      Date of defense: 25. 4. 2013
      Background: The apoptosome pathway is interesting as potential therapeutic target because it plays an important role in the cancer chemotherapy- and biological therapy-induced apoptosis as well as in amplifying the death ...

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